Overview

  • Product name

    Anti-HTLV I gp46 antibody [65/6C2.2.34]
    See all HTLV I gp46 primary antibodies
  • Description

    Mouse monoclonal [65/6C2.2.34] to HTLV I gp46
  • Host species

    Mouse
  • Specificity

    Human T-Lymphotropic Virus Type I (HTLV I) surface protein, gp46 and with MTA-4 recombinant HTLV I env. Reacts with formalin fixed tissue. Cross-reactivity with the surface protein HTLV II (moT) has been observed.
  • Tested applications

    Suitable for: WB, Radioimmunoprecipitation, ELISA, ICC/IFmore details
  • Species reactivity

    Reacts with: Other species
  • Immunogen

    Synthetic peptide corresponding to HTLV I gp46 aa 210-306.

  • Epitope

    The epitope is located between amino acids 210-306 of the viral env gene.
  • General notes

    The antibody is used to detect HTLV I surface protein and its precursor in lysates prepared from virons or infected cells. Using immunoblotting and/or radioimmunoprecipitation analysis, the biosynthesis and metabolism of viral surface protein may be studied.

    Antibody dilutions should be prepared using buffers containing suitable protein in order to stabilize antibody activity.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage buffer

    Constituent: PBS
  • Concentration information loading...
  • Purity

    Ammonium Sulphate Precipitation
  • Purification notes

    Purified from serum-free culture supernatant. The antibody is greater than 85% pure as determined using denaturing polyacrylamide gel electrophoresis.
  • Primary antibody notes

    The antibody is used to detect HTLV I surface protein and its precursor in lysates prepared from virons or infected cells. Using immunoblotting and/or radioimmunoprecipitation analysis, the biosynthesis and metabolism of viral surface protein may be studied.
  • Clonality

    Monoclonal
  • Clone number

    65/6C2.2.34
  • Isotype

    IgG1
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab9086 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 10 µg/ml.
Radioimmunoprecipitation Use at an assay dependent concentration.
ELISA Use at an assay dependent concentration.
ICC/IF Use a concentration of 1 - 10 µg/ml.

Target

  • Relevance

    HTLV I gp46 surface protein is processed from its precursor gp62. It attaches the virus to the host cell by binding to its receptor. This interaction triggers the refolding of the transmembrane protein (TM) and is thought to activate its fusogenic potential by unmasking its fusion peptide. Fusion occurs at the host cell plasma membrane.
  • Cellular localization

    Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein
  • Database links

    • Alternative names

      • Glycoprotein 46 antibody
      • SU antibody
      • Surface protein antibody

    References

    ab9086 has not yet been referenced specifically in any publications.

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