Key features and details
- Mouse monoclonal [46/3.24.4] to HTLV I p24
- Suitable for: Radioimmunoprecipitation, WB, ELISA
- Isotype: IgG1
Product nameAnti-HTLV I p24 antibody [46/3.24.4]
DescriptionMouse monoclonal [46/3.24.4] to HTLV I p24
SpecificityReacts with Human T-Lymphotropic Virus Type I (HTLV I) core p24. Cross reactivity with p24 from HTLV II has been observed.
Tested applicationsSuitable for: Radioimmunoprecipitation, WB, ELISAmore details
Species reactivityReacts with: Other species
HTVL viral lysate
The antibody is used to detect HTLV I core protein in viral or infected cell lysates. Studies on core antigen synthesis and metabolism can be performed using Western blotting or radioimmunoprecipitation analysis. The antibody is also valuable for the affinity isolation of HTLV I core protein.
Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.
Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.
We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.
In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
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Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage bufferpH: 7.2
Concentration information loading...
PurityProtein A purified
Purification notesPurified from serum-free culture supernatant.
Primary antibody notesThe antibody is used to detect HTLV I core protein in viral or infected cell lysates. Studies on core antigen synthesis and metabolism can be performed using Western blotting or radioimmunoprecipitation analysis. The antibody is also valuable for the affinity isolation of HTLV I core protein.
Our Abpromise guarantee covers the use of ab9081 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|Radioimmunoprecipitation||Use at an assay dependent concentration.|
|WB||Use a concentration of 1 - 10 µg/ml.
Antibody dilutions should be prepared using buffers containing suitable protein in order to stabilize antibody activity.
|ELISA||Use at an assay dependent concentration.|
RelevanceHuman T-lymphotropic virus (HTLV) belongs to the family Retroviridae, genus Deltaretrovirus. It is a human, single-stranded RNA retrovirus that causes T-cell leukemia and T-cell lymphoma in adults and may also be involved in certain demyelinating diseases. Adult T-lymphotropic virus (ATLV) is a strain of this disease that effect primarily adults. Capsid protein p24 probably forms the conical core of the virus that encapsulates the genomic RNA-nucleocapsid complex.
Cellular localizationCore protein
- CA antibody
- Capsid protein p24 antibody
- p24 antibody
ab9081 has been referenced in 3 publications.
- Martin-Latil S et al. Transcytosis of HTLV-1 across a tight human epithelial barrier and infection of subepithelial dendritic cells. Blood 120:572-80 (2012). PubMed: 22589473
- Grigsby IF et al. Biophysical analysis of HTLV-1 particles reveals novel insights into particle morphology and Gag stochiometry. Retrovirology 7:75 (2010). WB, ICC/IF . PubMed: 20854688
- Afonso PV et al. Alteration of blood-brain barrier integrity by retroviral infection. PLoS Pathog 4:e1000205 (2008). WB, ICC/IF . PubMed: 19008946