HTMT (Histamine trifluoromethyl toluidide) dimaleate, H1/H2 receptor agonist (ab141127)

Overview

  • Product name

    HTMT (Histamine trifluoromethyl toluidide) dimaleate, H1/H2 receptor agonist
  • Description

    H1/H2 receptor agonist. More potent than histamine.
  • Biological description

    H1/H2 receptor agonist (Ki = 1.2 µM). More potent than histamine (ab120734). Activates IP3/Ca2+ signaling and induces proliferation of small cholangiocytes. Active in vivo.
  • Purity

    > 99%
  • CAS Number

    195867-54-0
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    6-[[2-(1H-Imidazol-5-yl)ethyl]amino]-N-[4-(trifluoromethyl)phenyl]heptanamide dimaleate
  • Molecular weight

    614.57
  • Molecular formula

    C19H25F3N4O.2C4H4O4
  • PubChem identifier

    57357684
  • Storage instructions

    Store at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 100 mM and in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    O=C(O)\C=C/C(=O)O.O=C(O)\C=C/C(=O)O.FC(F)(F)c1ccc(cc1)NC(=O)CCCCC(C)NCCc2cncn2
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Francis H  et al. Small mouse cholangiocytes proliferate in response to H1 histamine receptor stimulation by activation of the IP3/CaMK I/CREB pathway. Am J Physiol Cell Physiol 295:C499-513 (2008). Read more (PubMed: 18508907) »
  • Zhu Y  et al. Cloning, expression, and pharmacological characterization of a novel human histamine receptor. Mol Pharmacol 59:434-41 (2001). Read more (PubMed: 11179436) »
  • Qiu R  et al. Effects of histamine-trifluoromethyl-toluidide derivative (HTMT) on intracellular calcium in human lymphocytes. J Pharmacol Exp Ther 253:1245-52 (1990). Read more (PubMed: 2359026) »
  • Tripathi T  et al. Modulation of in vivo immunoglobulin production by endogenous histamine and H1R and H2R agonists and antagonists. Pharmacol Rep 62:917-25 (0). Read more (PubMed: 21098875) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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