Overview

  • Product name

    Anti-HTR3C antibody
  • Description

    Rabbit polyclonal to HTR3C
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-P, WBmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Fusion protein corresponding to Human HTR3C (internal sequence). BC131799; The identity of the protein fusion partner is GST.
    Database link: Q8WXA8

  • Positive control

    • HT29 cell lysate; Human prostate cancer tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab199148 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/50 - 1/200. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
WB 1/200 - 1/1000. Predicted molecular weight: 50 kDa.

Target

  • Relevance

    HTR3C is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel.The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit C of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. Genes encoding subunits C, D and E form a cluster on chromosome 3.
  • Cellular localization

    Cell Membrane; Multi-pass membrane protein. Note: Presumably retained within the endoplasmic reticulum unless complexed with HTR3A
  • Database links

  • Alternative names

    • 5 HT3 C antibody
    • 5 HT3C antibody
    • 5 hydroxytryptamine (serotonin) receptor 3, family member C antibody
    • 5 hydroxytryptamine (serotonin) receptor 3C ionotropic antibody
    • 5 hydroxytryptamine receptor 3 subunit C antibody
    • 5 hydroxytryptamine receptor 3C antibody
    • Serotonin receptor 3C antibody
    see all

Images

  • Immunohistochemical analysis of paraffin-embedded Human prostate cancer tissue labeling HTR3C with ab199148 at 1/30 dilution.

  • Anti-HTR3C antibody (ab199148) at 1/500 dilution + HT29 cell lysate at 40 µg

    Developed using the ECL technique.

    Predicted band size: 50 kDa


    Exposure time: 20 seconds


    8% SDS-PAGE.

References

ab199148 has not yet been referenced specifically in any publications.

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