Recombinant
RabMAb

Recombinant Anti-HUCE1 antibody [EPR10645(B)] - BSA and Azide free (ab249234)

Overview

  • Product name
    Anti-HUCE1 antibody [EPR10645(B)] - BSA and Azide free
    See all HUCE1 primary antibodies
  • Description
    Rabbit monoclonal [EPR10645(B)] to HUCE1 - BSA and Azide free
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WB, IPmore details
    Unsuitable for: Flow Cyt or IHC-P
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide within Human HUCE1. The exact sequence is proprietary.
    Database link: O43159

  • General notes

    ab249234 is a PBS-only buffer format of ab155989. Please refer to ab155989 for recommended dilutions, protocols, and image data.

     

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents.

    This product is a recombinant rabbit monoclonal antibody.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Concentration information loading...
  • Purity
    Protein A purified
  • Clonality
    Monoclonal
  • Clone number
    EPR10645(B)
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab249234 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use at an assay dependent concentration. Predicted molecular weight: 51 kDa.
IP Use at an assay dependent concentration.
  • Application notes
    Is unsuitable for Flow Cyt or IHC-P.
  • Target

    • Function
      Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown.
    • Sequence similarities
      Belongs to the methyltransferase superfamily. RRP8 family.
    • Cellular localization
      Nucleus > nucleolus. Localizes at rDNA locus.
    • Information by UniProt
    • Database links
    • Alternative names
      • Cerebral protein 1 antibody
      • hypothetical protein LOC23378 antibody
      • KIAA0409 antibody
      • NML antibody
      • Nucleomethylin antibody
      • Ribosomal RNA processing 8 methyltransferase homolog antibody
      • Ribosomal RNA processing 8, methyltransferase, homolog (yeast) antibody
      • Ribosomal RNA processing protein 8 antibody
      • Ribosomal RNA-processing protein 8 antibody
      • RRP 8 antibody
      • RRP8 antibody
      • RRP8 methyltransferase homolog antibody
      • RRP8_HUMAN antibody
      see all

    References

    ab249234 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

    There are currently no Customer reviews or Questions for ab249234.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
    For licensing inquiries, please contact partnerships@abcam.com

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