Overview

Description

  • Nature
    Synthetic
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      C-NRNNSSGRVPTII
    • Amino acids
      845 to 857

Specifications

Our Abpromise guarantee covers the use of ab23095 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

General Info

  • Alternative names
    • AGAP 1
    • AGAP-1
    • Agap1
    • AGAP1_HUMAN
    • Arf GAP with GTP binding proteinlike ANK repeat and PH domains 1
    • Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1
    • ArfGAP with GTPase domain ankyrin repeat and PH domain 1
    • Centaurin gamma 2
    • Centaurin-gamma-2
    • CENTG2
    • Cnt-g2
    • GGAP 1
    • GGAP1
    • GTP binding and GTPase activating protein 1
    • GTP-binding and GTPase-activating protein 1
    • KIAA1099
    • MGC71657
    see all
  • Function
    GTPase-activating protein for ARF1 and, to a lesser extent, ARF5. Directly and specifically regulates the adapter protein 3 (AP-3)-dependent trafficking of proteins in the endosomal-lysosomal system.
  • Tissue specificity
    Widely expressed.
  • Sequence similarities
    Belongs to the centaurin gamma-like family.
    Contains 2 ANK repeats.
    Contains 1 Arf-GAP domain.
    Contains 1 PH domain.
  • Domain
    The PH domain mediates AP-3 binding.
  • Post-translational
    modifications
    Phosphorylated on tyrosines.
  • Cellular localization
    Cytoplasm. Associates with the endocytic compartment.
  • Information by UniProt

References

ab23095 has not yet been referenced specifically in any publications.

Publishing research using ab23095? Please let us know so that we can cite the reference in this datasheet.

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