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Amino Acid Sequence
1769 to 1782
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in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Blocking - Blocking peptide for Anti-AKAP12 antibody (ab9698)
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Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
- A kinase (PRKA) anchor protein (gravin) 12
- A kinase Anchor Protein 12
- A kinase anchor protein 250kDa
Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC).
Expressed in endothelial cells, cultured fibroblasts and osteosarcoma, but not in platelets, leukocytes, monocytic cell lines or peripherical blood cells.
Contains 3 AKAP domains.
Polybasic regions located between residues 266 and 557 are involved in binding PKC.
Phosphorylated upon DNA damage, probably by ATM or ATR.
Cytoplasm > cell cortex. Cytoplasm > cytoskeleton. May be part of the cortical cytoskeleton.
Information by UniProt
has not yet been referenced specifically in any publications.
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