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To refine my choice, I would like to know against which protein(s) (sequence or accesion number in Swissprot) are exactly directed antibodies used in the following Elisa kits: ab108884 ab108883 ab108823 ab108841 Thanks in advance
Asked on Nov 15 2011
Thank you for your inquiry. ab108884 is an alpha 1 microglobulin human ELISA kit, Swiss Prot P02760. Alpha1-microglobulin (1M), also called protein HC, is a tubular plasma and tissue protein that belongs to the lipocalin transport protein superfamily for small hydrophobic molecules. It contains 184 amino acids and weighs 26-kDa (1-2). Mature 1M and bikunin (urinary trypsin inhibitor) result from a common precursor (3). (1) Grubb AO et al. (1983) Biol Chem. 258:14698-14707 (2) Ekström B and Berggård I. (1977) J Biol Chem 252:8048-8057 (3) Vetr H and Gebhard W (1990) Biol Chem Hoppe Seyler. 371:1185-1196 https://www.abcam.com/alpha-1-Microglobulin-Human-ELISA-Kit-ab108884.html http://www.uniprot.org/uniprot/P02760#PRO_0000017886 ab108883 is an is an alpha 2 macroglobulin human ELISA kit, Swiss Prot P01023. It's a major serum protein. (1) Pineda-Salgado L et al (2005) Gene Expr Patterns. 6(1):3-10 (2) Jensen PE et al (2004) Biocim Biophys Acta. 5; 1690(3): 203-7 (3) Yang AH et al (1997) Nephrol Dial Transplant 12(3): 465-9 (4) Shiota G et al (1995) J Med 26(5-6): 295-308. https://www.abcam.com/alpha-2-Macroglobulin-Human-ELISA-Kit-ab108883.html http://www.uniprot.org/uniprot/P01023 ab108823 is a complement C3 human ELISA kit, Swiss Prot P01024. Complement protein C3 is the fourth component to attach in the complement reaction sequence. It is a beta-globulin with a sedimentation coefficient of 5.5 and a molecular weight of 185,000. (1) Sahu A et al. (2001) Immunol. Rev. 180: 35-48 (2) Sacks S et al. 92003) J Mol Med. 81(7): 404-10 (3) Ramos-Casals M et al. (2004) Rheumatology (Oxford). (4) Gardinali M et al. (1998) Clin.Immunol.Immunopathol .87(3): 97-303 https://www.abcam.com/Complement-C3-Human-ELISA-kit-ab108823.html http://www.uniprot.org/uniprot/P01024 ab108841 is a fibrinogen human ELISA kit, Swiss Prot P02671, P02675, and P02679. Fibrinogen (FBG) is a homodimer of molecular mass 340 kDa, made up of two sets of α, β, γ polypeptide chains, and synthesized in the parenchymal cell of the hepatocyte and in the megakaryocyte (1). FBG plays a major role in coagulation, and both elevated and decreased levels have clinical significance. Upon cleavage by thrombin in the initial stages of coagulation activation, FBG self-assembles to yield a fibrin clot matrix that subsequently is crosslinked by factor XIIIa to form an insoluble network. FBG also binds to the platelet glycoprotein IIbIIIa receptor so as to form bridges between platelets, thus facilitating aggregation (2). Elevated plasma FBG has been identified as an independent risk factor for coronary atherosclerosis and ischemic heart disease (3, 4). Individuals with congenital absence of FBG, termed afibrinogenemia, have prolonged bleeding times. (1) Doolittle, R.F. (1984) Annu. Rev. Biochem 53:195 (2) Handley, D.A. and Hughes, T.E. (1997) Thromb. Res. 87:1 (3) Handa, K. et al. (1989) Atherosclerosis 77:209 (4) Mannucci, P.M. and Mari, D. (1993) Fibrinolysis 3:51 (5) Amiral J. (1995) Clin. Appl. Thrombosis Hemostasis 1:243 http://www.uniprot.org/uniprot/P02671 http://www.uniprot.org/uniprot/P02675 http://www.uniprot.org/uniprot/P02679 I hope this information helps. Please contact us with any other questions.
Answered on Nov 15 2011