Human Apolipoprotein B peptide (ab50068)

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Description

Associated products

    Specifications

    Our Abpromise guarantee covers the use of ab50068 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • Form

      Liquid

    • Additional notes

      - First try to dissolve a small amount of peptide in either water or buffer. The more charged residues on a peptide, the more soluble it is in aqueous solutions.
      - If the peptide doesn’t dissolve try an organic solvent e.g. DMSO, then dilute using water or buffer.
      - Consider that any solvent used must be compatible with your assay. If a peptide does not dissolve and you need to recover it, lyophilise to remove the solvent.
      - Gentle warming and sonication can effectively aid peptide solubilisation. If the solution is cloudy or has gelled the peptide may be in suspension rather than solubilised.
      - Peptides containing cysteine are easily oxidised, so should be prepared in solution just prior to use.

    • Concentration information loading...

    Preparation and Storage

    • Stability and Storage

      Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

      Information available upon request.

    General Info

    • Alternative names

      • Apo B
      • Apo B 100
      • Apo B-100
      • Apo B-48
      • Apo B100
      • Apo B48
      • APOB
      • ApoB 100
      • ApoB 48
      • APOB_HUMAN
      • Apolipoprotein B
      • Apolipoprotein B (including Ag(x) antigen)
      • Apolipoprotein B 100
      • Apolipoprotein B 48
      • Apolipoprotein B-48
      • Apolipoprotein B100
      • Apolipoprotein B48
      • FLDB
      • LDLCQ4
      see all

    • Function

      Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B-100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor.

    • Involvement in disease

      Hypobetalipoproteinemia, familial, 1
      Familial ligand-defective apolipoprotein B-100
      Defects in APOB associated with defects in other genes (polygenic) can contribute to hypocholesterolemia.

    • Sequence similarities

      Contains 1 vitellogenin domain.

    • Post-translational
      modifications

      Palmitoylated; structural requirement for proper assembly of the hydrophobic core of the lipoprotein particle.

    • Cellular localization

      Cytoplasm. Secreted.
    • Information by UniProt

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    References (0)

    Publishing research using ab50068? Please let us know so that we can cite the reference in this datasheet.

    ab50068 has not yet been referenced specifically in any publications.

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