Description

Associated products

Specifications

Our Abpromise guarantee covers the use of ab88220 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-Apolipoprotein CII/ApoC-II antibody (ab76452)

  • Form

    Liquid
  • Additional notes

    - First try to dissolve a small amount of peptide in either water or buffer. The more charged residues on a peptide, the more soluble it is in aqueous solutions.
    - If the peptide doesn’t dissolve try an organic solvent e.g. DMSO, then dilute using water or buffer.
    - Consider that any solvent used must be compatible with your assay. If a peptide does not dissolve and you need to recover it, lyophilise to remove the solvent.
    - Gentle warming and sonication can effectively aid peptide solubilisation. If the solution is cloudy or has gelled the peptide may be in suspension rather than solubilised.
    - Peptides containing cysteine are easily oxidised, so should be prepared in solution just prior to use.

     This product was previously labelled as Apolipoprotein CII

     

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Information available upon request.

General Info

  • Alternative names

    • APC 2
    • APC2
    • Apo CII
    • Apo-CII
    • APOC 2
    • ApoC II
    • ApoC-II
    • APOC2
    • APOC2 protein
    • APOC2_HUMAN
    • ApoCII
    • Apolipoprotein C II
    • Apolipoprotein C II precursor
    • Apolipoprotein C2
    • ApolipoproteinCII
    • MGC75082
    • ProapoC-II
    • Proapolipoprotein C-II
    see all
  • Function

    Component of chylomicrons, very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) in plasma. Plays an important role in lipoprotein metabolism as an activator of lipoprotein lipase. Both proapolipoprotein C-II and apolipoprotein C-II can activate lipoprotein lipase. In normolipidemic individuals, it is mainly distributed in the HDL, whereas in hypertriglyceridemic individuals, predominantly found in the VLDL and LDL.
  • Tissue specificity

    Liver and intestine.
  • Involvement in disease

    Hyperlipoproteinemia 1B
  • Sequence similarities

    Belongs to the apolipoprotein C2 family.
  • Post-translational
    modifications

    Proapolipoprotein C-II is synthesized as a sialic acid containing glycoprotein which is subsequently desialylated prior to its proteolytic processing.
    Proapolipoprotein C-II, the major form found in plasma undergoes proteolytic cleavage of its N-terminal hexapeptide to generate apolipoprotein C-II, which occurs as the minor form in plasma.
  • Cellular localization

    Secreted.
  • Information by UniProt

References

ab88220 has not yet been referenced specifically in any publications.

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