Human BCRP/ABCG2 peptide (ab100820)

Submit an Abreview Q&A (1)

Overview

Description

  • Nature
    Synthetic
  • Amino Acid Sequence
    • Species
      Human
    • Molecular weight
      72 kDa

Associated products

Specifications

Our Abpromise guarantee covers the use of ab100820 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Purity
    70 - 90% by HPLC.

  • Form
    Liquid
  • Additional notes

    - First try to dissolve a small amount of peptide in either water or buffer. The more charged residues on a peptide, the more soluble it is in aqueous solutions.
    - If the peptide doesn’t dissolve try an organic solvent e.g. DMSO, then dilute using water or buffer.
    - Consider that any solvent used must be compatible with your assay. If a peptide does not dissolve and you need to recover it, lyophilise to remove the solvent.
    - Gentle warming and sonication can effectively aid peptide solubilisation. If the solution is cloudy or has gelled the peptide may be in suspension rather than solubilised.
    - Peptides containing cysteine are easily oxidised, so should be prepared in solution just prior to use.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Information available upon request.

General Info

  • Alternative names
    • ABC transporter
    • ABC15
    • ABCG 2
    • ABCG2
    • ABCG2_HUMAN
    • ABCP
    • ATP binding cassette sub family G (WHITE) member 2
    • ATP binding cassette transporter G2
    • ATP-binding cassette sub-family G member 2
    • BCRP
    • BCRP1
    • BMDP
    • Breast cancer resistance protein
    • CD338
    • CDw338
    • CDw338 antigen
    • EST157481
    • GOUT1
    • MGC102821
    • Mitoxantrone resistance associated protein
    • Mitoxantrone resistance-associated protein
    • MRX
    • Multi drug resistance efflux transport ATP binding cassette sub family G (WHITE) member 2
    • MXR
    • MXR1
    • Placenta specific ATP binding cassette transporter
    • Placenta specific MDR protein
    • Placenta-specific ATP-binding cassette transporter
    • UAQTL1
    see all
  • Function
    Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. May be involved in brain-to-blood efflux. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. When overexpressed, the transfected cells become resistant to mitoxantrone, daunorubicin and doxorubicin, display diminished intracellular accumulation of daunorubicin, and manifest an ATP-dependent increase in the efflux of rhodamine 123.
  • Tissue specificity
    Highly expressed in placenta. Low expression in small intestine, liver and colon.
  • Sequence similarities
    Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
    Contains 1 ABC transmembrane type-2 domain.
    Contains 1 ABC transporter domain.
  • Post-translational
    modifications
    Glycosylation-deficient ABCG2 is normally expressed and functional.
  • Cellular localization
    Cell membrane.
  • Information by UniProt

References

ab100820 has not yet been referenced specifically in any publications.

Publishing research using ab100820? Please let us know so that we can cite the reference in this datasheet.

Customer reviews and Q&As

Submit a review Submit a question

1 Review or Q&A

10
Votes: Highest First

We probed human placenta samples (60 ug) for the efflux transporter BCRP using your BCRP/ABCG2 primary antibody (ab63907, lot no: GR42347) for the first time. Our positive controls were mouse kidney lysates and human embryonic kidney (HEK) cells that o...

Read More

Thank you for taking time to contact us. I am sorry to hear that this antibody is not providing satisfactory results.

The details provided will enable us to investigate this case and will provide us with vital information for monitoring prod...

Read More

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

Sign up