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  1. Link

    human-bdnf-peptide-ab182199.pdf

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Neuroscience Neurology process Growth and Development Neurotrophins
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Human BDNF peptide (ab182199)

  • Datasheet
Submit a review Submit a question References (3)

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Key features and details

  • Suitable for: Blocking

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Description

  • Product name

    Human BDNF peptide
    See all BDNF proteins and peptides
  • Accession

    P23560
  • Animal free

    No
  • Nature

    Synthetic
    • Species

      Human

Associated products

  • Corresponding Antibody

    • Anti-BDNF antibody [EPR1292] (ab108319)

Specifications

Our Abpromise guarantee covers the use of ab182199 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-BDNF antibody [EPR1292] (ab108319)

  • Form

    Lyophilized
  • Additional notes

    This is the blocking peptide for ab108319

    - First try to dissolve a small amount of peptide in either water or buffer. The more charged residues on a peptide, the more soluble it is in aqueous solutions.
    - If the peptide doesn’t dissolve try an organic solvent e.g. DMSO, then dilute using water or buffer.
    - Consider that any solvent used must be compatible with your assay. If a peptide does not dissolve and you need to recover it, lyophilise to remove the solvent.
    - Gentle warming and sonication can effectively aid peptide solubilisation. If the solution is cloudy or has gelled the peptide may be in suspension rather than solubilised.
    - Peptides containing cysteine are easily oxidised, so should be prepared in solution just prior to use.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot. Store at -20°C long term.

    Information available upon request.

General Info

  • Alternative names

    • Abrineurin
    • ANON2
    • BDNF
    • BDNF_HUMAN
    • Brain Derived Neurotrophic Factor
    • Brain-derived neurotrophic factor
    • BULN2
    • MGC34632
    • Neurotrophin
    see all
  • Function

    During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability.
  • Tissue specificity

    Brain. Highly expressed in hippocampus, amygdala, cerebral cortex and cerebellum. Also expressed in heart, lung, skeletal muscle, testis, prostate and placenta.
  • Involvement in disease

    Bulimia nervosa 2
    Congenital central hypoventilation syndrome
  • Sequence similarities

    Belongs to the NGF-beta family.
  • Post-translational
    modifications

    The propeptide is N-glycosylated and glycosulfated.
    Converted into mature BDNF by plasmin (PLG).
  • Cellular localization

    Secreted.
  • Target information above from: UniProt accession P23560 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

Datasheets and documents

  • Datasheet download

    Download

References (3)

Publishing research using ab182199? Please let us know so that we can cite the reference in this datasheet.

ab182199 has been referenced in 3 publications.

  • Lee HW  et al. Effects of exercise on BDNF-TrkB signaling in the paraventricular nucleus and rostral ventrolateral medulla in rats post myocardial infarction. Neuropeptides N/A:102058 (2020). PubMed: 32507324
  • Ma Z  et al. Alpha-synuclein is involved in manganese-induced spatial memory and synaptic plasticity impairments via TrkB/Akt/Fyn-mediated phosphorylation of NMDA receptors. Cell Death Dis 11:834 (2020). PubMed: 33033239
  • Matsuzaka Y  et al. The nSMase2/Smpd3 gene modulates the severity of muscular dystrophy and the emotional stress response in mdx mice. BMC Med 18:343 (2020). PubMed: 33208172

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