Key features and details
- Sensitivity: 5 U/ml
- Range: 5 U/ml - 240 U/ml
- Sample type: Serum
- Detection method: Colorimetric
- Assay type: Sandwich (quantitative)
- Reacts with: Human
Product nameHuman Cancer Antigen CA15-3 ELISA Kit
Assay typeSandwich (quantitative)
Sensitivity= 5 U/ml
Range5 U/ml - 240 U/ml
Assay durationMultiple steps standard assay
Species reactivityReacts with: Human
ab108633 Cancer Antigen CA15-3 Human ELISA Kit is intended for the quantitative determination of the Cancer Antigen CA15-3 concentration in human serum.
Breast cancer is the most common life-threatening malignant lesion in women of many developed countries today, with approximately 180,000 new cases diagnosed every year.
There are a number of tumor markers that can help clinicians to identify and diagnose which breast cancer patients will have aggressive disease and which will have an indolent course. These markers include estrogen and progesterone receptors, DNA ploidy and percent-S phase profile, epidermal growth factor receptor, HER-2/neu oncogene, p53 tumor suppressor gene, cathepsin D, proliferation markers and CA15-3. CA15-3 is most useful for monitoring patients post-operatively for recurrence, particularly metastatic diseases. 96% of patients with local and systemic recurrence have elevated CA15-3, which can be used to predict recurrence earlier than radiological and clinical criteria. A 25% increase in the serum CA15-3 is associated with progression of carcinoma. A 50% decrease in serum CA15-3 is associated with response to treatment. CA15-3 is more sensitive than CEA in early detection of breast cancer recurrence.
Storage instructionsStore at +4°C. Please refer to protocols.
Components 1 x 96 tests 20X Washing Solution 1 x 50ml CA15-3 Standard 1 - 0 U/mL 1 unit CA15-3 Standard 2 - 15 U/mL 1 unit CA15-3 Standard 3 - 30 U/mL 1 unit CA15-3 Standard 4 - 60 U/mL 1 unit CA15-3 Standard 5 - 120 U/mL 1 unit CA15-3 Standard 6 - 240 U/mL 1 unit Enzyme Conjugate Concentrate 1 x 1ml Enzyme Conjugate Diluent 1 x 21ml IgG Sample Diluent 1 x 100ml Mouse Monoclonal anti-CA15-3 coated microtiter plate 1 unit Stop Solution 1 x 11ml TMB Reagent 1 x 11ml
ab108633 has been referenced in 1 publication.
- Dowling P et al. Transferrin-bound proteins as potential biomarkers for advanced breast cancer patients. BBA Clin 2:24-30 (2014). PubMed: 26673961