Description

Associated products

Specifications

Our Abpromise guarantee covers the use of ab22991 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-CBR1 antibody (ab4148)

  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

General Info

  • Alternative names

    • 15 hydroxyprostaglandin dehydrogenase [NADP+]
    • 15-hydroxyprostaglandin dehydrogenase [NADP+]
    • Carbonyl reductase [NADPH] 1
    • Carbonyl Reductase 1
    • CBR 1
    • CBR1
    • CBR1_HUMAN
    • CRN
    • NADPH dependent carbonyl reductase 1
    • NADPH-dependent carbonyl reductase 1
    • Prostaglandin 9 ketoreductase
    • Prostaglandin 9-ketoreductase
    • Prostaglandin E(2) 9 reductase
    • Prostaglandin-E(2) 9-reductase
    • SDR21C1
    see all
  • Function

    NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2-alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione.
  • Sequence similarities

    Belongs to the short-chain dehydrogenases/reductases (SDR) family.
  • Cellular localization

    Cytoplasm.
  • Information by UniProt

References

ab22991 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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