Overview

  • Product name

    Human Coronin 1a Antibody Pair - BSA and Azide free
    See all Coronin 1a/TACO kits
  • Detection method

    Colorimetric
  • Assay type

    ELISA set
  • Range

    39.1 pg/ml - 2500 pg/ml
  • Species reactivity

    Reacts with: Human
  • Product overview

    The Antibody Pair can be used to quantify Human Coronin 1a. BSA and Azide free antibody pairs include unconjugated capture and detector antibodies suitable for sandwich ELISAs. The antibodies are provided at an approximate concentration of 1 mg/ml as measured by the protein A280 method. The recommended antibody orientation is based on internal optimization for ELISA-based assays. Antibody orientation is assay dependent and needs to be optimized for each assay type. Both capture and detector antibodies are rabbit monoclonal antibodies delivering consistent, specific, and sensitive results.


    For additional information on the performance of the antibody pair, see the equivalent SimpleStep ELISA® Kit (ab214032), which uses the same antibodies. Please note that the range provided for the pairs is only an estimation based on the performance of the related product using the same antibody pair. Performance of the antibody pair will depend on the specific characteristics of your assay. We guarantee the product works in sandwich ELISA, but we do not guarantee the sensitivity or dynamic range of the antibody pair in your assay.


    To receive an electronic copy of the Certificate of Analysis, please send an email to technical support with "CoA for matched antibody pair kit" in the subject line and the desired product number and lot number in the body of the email.


    Download SDS here.


     

  • Tested applications

    Suitable for: ELISAmore details
  • Platform

    Reagents

Properties

  • Storage instructions

    Store at +4°C. Please refer to protocols.
  • Components 10 x 96 tests
    Human Coronin 1a Capture Antibody 1 x 100µg
    Human Coronin 1a Detector Antibody 1 x 100µg
  • Research areas

  • Function

    May be a crucial component of the cytoskeleton of highly motile cells, functioning both in the invagination of large pieces of plasma membrane, as well as in forming protrusions of the plasma membrane involved in cell locomotion. In mycobacteria-infected cells, its retention on the phagosomal membrane prevents fusion between phagosomes and lysosomes.
  • Tissue specificity

    Expressed in brain, thymus, spleen, bone marrow and lymph node. Low in lung and gut.
  • Sequence similarities

    Belongs to the WD repeat coronin family.
    Contains 7 WD repeats.
  • Cellular localization

    Cytoplasm > cytoskeleton. Cytoplasm > cell cortex. Cytoplasmic vesicle > phagosome membrane. In non-infected macrophages, associated with the cortical microtubule network. In mycobacteria-infected macrophages, becomes progressively relocalized and retained around the mycobacterial phagosomes. Retention on the phagosomal membrane is strictly dependent on mycobacterial viability and not due to impaired acidification.
  • Information by UniProt
  • Alternative names

    • Actin binding protein
    • CLABP
    • Clipin A
    • Clipin-A
    • CLIPINA
    • COR1A_HUMAN
    • CORO1A
    • Coronin 1
    • Coronin actin binding protein 1A
    • Coronin like protein A
    • Coronin like protein p57
    • Coronin-1A
    • Coronin-like protein A
    • Coronin-like protein p57
    • FLJ41407
    • HCORO1
    • MGC117380
    • OTTHUMP00000163017
    • p57
    • TACO
    • Tryptophan aspartate containing coat protein
    • Tryptophan aspartate-containing coat protein
    see all
  • Database links

Associated products

Applications

Our Abpromise guarantee covers the use of ab241846 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA Use at an assay dependent concentration.

References

ab241846 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab241846.
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