Description

  • Product name

    Human Cubilin peptide
  • Purity

    70 - 90% by HPLC.

  • Animal free

    No
  • Nature

    Synthetic
    • Species

      Human

Specifications

Our Abpromise guarantee covers the use of ab68599 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking

  • Form

    Liquid
  • Additional notes

    - First try to dissolve a small amount of peptide in either water or buffer. The more charged residues on a peptide, the more soluble it is in aqueous solutions.
    - If the peptide doesn’t dissolve try an organic solvent e.g. DMSO, then dilute using water or buffer.
    - Consider that any solvent used must be compatible with your assay. If a peptide does not dissolve and you need to recover it, lyophilise to remove the solvent.
    - Gentle warming and sonication can effectively aid peptide solubilisation. If the solution is cloudy or has gelled the peptide may be in suspension rather than solubilised.
    - Peptides containing cysteine are easily oxidised, so should be prepared in solution just prior to use.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Information available upon request.

General Info

  • Alternative names

    • 460 kDa receptor
    • Cubilin
    • cubilin (intrinsic factor-cobalamin receptor)
    • Cubilin precursor
    • Cubn
    • CUBN_HUMAN
    • IFCR
    • Intestinal intrinsic factor receptor
    • intrinsic factor B12-receptor
    • Intrinsic factor-cobalamin receptor
    • Intrinsic factor-vitamin B12 receptor
    • megaloblastic anemia 1
    • MGA1
    see all
  • Function

    Cotransporter which plays a role in lipoprotein, vitamin and iron metabolism, by facilitating their uptake. Binds to ALB, MB, Kappa and lambda-light chains, TF, hemoglobin, GC, SCGB1A1, APOA1, high density lipoprotein, and the GIF-cobalamin complex. The binding of all ligands requires calcium. Serves as important transporter in several absorptive epithelia, including intestine, renal proximal tubules and embryonic yolk sac. Interaction with LRP2 mediates its trafficking throughout vesicles and facilitates the uptake of specific ligands like GC, hemoglobin, ALB, TF and SCGB1A1. Interaction with AMN controls its trafficking to the plasma membrane and facilitates endocytosis of ligands. May play an important role in the development of the peri-implantation embryo through internalization of APOA1 and cholesterol. Binds to LGALS3 at the maternal-fetal interface.
  • Tissue specificity

    Expressed in kidney proximal tubule cells, placenta, visceral yolk-sac cells and in absorptive intestinal cells. Expressed in the epithelium of intestine and kidney.
  • Involvement in disease

    Recessive hereditary megaloblastic anemia 1
  • Sequence similarities

    Contains 27 CUB domains.
    Contains 7 EGF-like domains.
  • Domain

    The CUB domains 5 to 8 mediate binding to GIF and ALB. CUB domains 1 and 2 mediate interaction with LRP2.
  • Post-translational
    modifications

    The precursor is cleaved by a trans-Golgi proteinase furin. The result is a propeptide cleaved off.
    N-glycosylated.
  • Cellular localization

    Endosome membrane. Lysosome membrane. Colocalizes with AMN and LRP2 in the endocytotic apparatus of epithelial cells.
  • Information by UniProt

References

ab68599 has not yet been referenced specifically in any publications.

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