The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
CAP GLY domain containing linker protein 2
CAP-Gly domain-containing linker protein 2
cytoplasmic linker 2
Cytoplasmic linker protein 115
Cytoplasmic linker protein 2
Similar to RESTIN (CYTOPLASMIC LINKER PROTEIN 170 ALPHA 2)
Williams Beuren syndrome chromosome region 3
Williams Beuren syndrome chromosome region 4
Williams-Beuren syndrome chromosomal region 3 protein
Williams-Beuren syndrome chromosomal region 4 protein
Seems to link microtubules to dendritic lamellar body (DLB), a membranous organelle predominantly present in bulbous dendritic appendages of neurons linked by dendrodendritic gap junctions. May operates in the control of brain-specific organelle translocations.
Involvement in disease
Note=CLIP2 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of CLIP2 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease.
Contains 2 CAP-Gly domains.
Cytoplasm. Cytoplasm > cytoskeleton. Associated with the cytoskeleton.