Description

Associated products

Specifications

Our Abpromise guarantee covers the use of ab234892 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-Cytochrome P450 3A4/CYP3A4 antibody [EPR6202] (ab124921)

  • Form

    Lyophilised
  • Additional notes

    - First try to dissolve a small amount of peptide in either water or buffer. The more charged residues on a peptide, the more soluble it is in aqueous solutions.

    - If the peptide doesn’t dissolve try an organic solvent e.g. DMSO, then dilute using water or buffer.

    - Consider that any solvent used must be compatible with your assay. If a peptide does not dissolve and you need to recover it, lyophilise to remove the solvent.

    - Gentle warming and sonication can effectively aid peptide solubilisation. If the solution is cloudy or has gelled the peptide may be in suspension rather than solubilised.

    - Peptides containing cysteine are easily oxidised, so should be prepared in solution just prior to use.

     This product was previously labelled as Cytochrome P450 3A4

     

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20°C. Avoid freeze / thaw cycle.

General Info

  • Alternative names

    • 1,8-cineole 2-exo-monooxygenase
    • Albendazole monooxygenase
    • Albendazole sulfoxidase
    • CP33
    • CP34
    • CP3A4_HUMAN
    • CYP3
    • CYP3A
    • CYP3A3
    • CYP3A4
    • CYPIIIA3
    • CYPIIIA4
    • Cytochrome P450 3A3
    • Cytochrome P450 3A4
    • Cytochrome P450 family 3 subfamily A polypeptide 4
    • Cytochrome P450 HLp
    • Cytochrome P450 NF-25
    • Cytochrome P450 subfamily IIIA polypeptide 4
    • cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 3
    • cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4
    • Cytochrome P450-PCN1
    • Glucocorticoid inducible P450
    • HLP
    • MGC126680
    • NF 25
    • NF25
    • Nifedipine oxidase
    • P450 III steroid inducible
    • P450 PCN1
    • P450, family III
    • P450C3
    • P450PCN1
    • Quinine 3 monooxygenase
    • Quinine 3-monooxygenase
    • Taurochenodeoxycholate 6 alpha hydroxylase
    • Taurochenodeoxycholate 6-alpha-hydroxylase
    see all
  • Function

    Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. The enzyme also hydroxylates etoposide.
  • Tissue specificity

    Expressed in prostate and liver. According to some authors, it is not expressed in brain (PubMed:19094056). According to others, weak levels of expression are measured in some brain locations (PubMed:19359404 and PubMed:18545703). Also expressed in epithelium of the small intestine and large intestine, bile duct, nasal mucosa, kidney, adrenal cortex, epithelium of the gastric mucosa with intestinal metaplasia, gallbladder, intercalated ducts of the pancreas, chief cells of the parathyroid and the corpus luteum of the ovary (at protein level).
  • Sequence similarities

    Belongs to the cytochrome P450 family.
  • Post-translational
    modifications

    Polyubiquitinated in the presence of AMFR and UBE2G1 and also STUB1/CHIP and UBE2D1 (in vitro).
  • Cellular localization

    Endoplasmic reticulum membrane. Microsome membrane.
  • Information by UniProt

References

ab234892 has not yet been referenced specifically in any publications.

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