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  1. Link

    human-cytosolic-phospholipase-a2-peptide-ab86259.pdf

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Immunology Innate Immunity Macrophage / Inflamm.
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Human Cytosolic Phospholipase A2 peptide (ab86259)

  • Datasheet
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Key features and details

  • Purity: > 70% HPLC

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Description

  • Product name

    Human Cytosolic Phospholipase A2 peptide
    See all Cytosolic Phospholipase A2 proteins and peptides
  • Purity

    > 70 % HPLC.
    70 - 90% by HPLC
  • Animal free

    No
  • Nature

    Synthetic
    • Species

      Human

Associated products

  • Corresponding Antibody

    • Anti-Cytosolic Phospholipase A2 antibody (ab73406)

Specifications

Our Abpromise guarantee covers the use of ab86259 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Form

    Liquid
  • Additional notes

    - First try to dissolve a small amount of peptide in either water or buffer. The more charged residues on a peptide, the more soluble it is in aqueous solutions.
    - If the peptide doesn’t dissolve try an organic solvent e.g. DMSO, then dilute using water or buffer.
    - Consider that any solvent used must be compatible with your assay. If a peptide does not dissolve and you need to recover it, lyophilise to remove the solvent.
    - Gentle warming and sonication can effectively aid peptide solubilisation. If the solution is cloudy or has gelled the peptide may be in suspension rather than solubilised.
    - Peptides containing cysteine are easily oxidised, so should be prepared in solution just prior to use.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Information available upon request.

General Info

  • Alternative names

    • Calcium dependent phospholipid binding protein
    • CPLA 2
    • cPLA2
    • cPLA2 alpha
    • Cytosolic phospholipase A2
    • Cytosolic phospholipase A2 group IVA
    • Lysophospholipase
    • MGC126350
    • PA24A_HUMAN
    • Phosphatidylcholine 2 acylhydrolase
    • Phosphatidylcholine 2-acylhydrolase
    • Phospholipase A2 group 4 A
    • Phospholipase A2 group IVA
    • Phospholipase A2 group IVA (cytosolic calcium dependent)
    • PhospholipaseA2
    • PLA2G4
    • pla2g4a
    see all
  • Function

    Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response.
  • Tissue specificity

    Expressed in various tissues such as macrophages, platelets, neutrophils, fibroblasts and lung endothelium.
  • Sequence similarities

    Contains 1 C2 domain.
    Contains 1 PLA2c domain.
  • Domain

    The N-terminal C2 domain associates with lipid membranes upon calcium binding. It modulates enzyme activity by presenting the active site to its substrate in response to elevations of cytosolic Ca(2+).
  • Post-translational
    modifications

    Activated by phosphorylation at both Ser-505 and Ser-727.
  • Cellular localization

    Cytoplasm. Cytoplasmic vesicle. Translocates to membrane vesicles in a calcium-dependent fashion.
  • Target information above from: UniProt accession P47712 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

Datasheets and documents

  • Datasheet download

    Download

References (0)

Publishing research using ab86259? Please let us know so that we can cite the reference in this datasheet.

ab86259 has not yet been referenced specifically in any publications.

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