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Inquiry: I have a two questions regarding the activity of ab90637 (human DLL4 peptide). 1. Is this peptide capable of activating the Notch pathway when it is immobilized and cultured with Notch1 or Notch4 expressing target cells? 2. What is the length of the peptide? Thanks
Asked on Jul 18 2012
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This peptide is 15 amino acids in length.We have not tested whether this product might be capable of activating the Notch pathway when it is immobilized and cultured with Notch1 or Notch4. However, the Delta-Serrate-Lag2 (DSL) domain (aa173-217) is located outside of the peptide range and is required for binding to the Notch receptor.
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Answered on Jul 18 2012