Product nameHuman DR4 peptide
See all DR4 proteins and peptides
Amino Acid Sequence
SequenceCDSGKFIYLEDGTGSAVSLE Amino acids 427 to 445 of human DR4 (1)
Amino acids450 to 468
Our Abpromise guarantee covers the use of ab8446 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Blocking - Blocking peptide for Anti-DR4 antibody (ab8414)
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
PBS with 0.1% BSA 0.02% sodium azide pH7.2
- Cytotoxic TRAIL receptor
FunctionReceptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B.
Tissue specificityWidely expressed. High levels are found in spleen, peripheral blood leukocytes, small intestine and thymus, but also in K562 erythroleukemia cells, MCF7 breast carcinoma cells and activated T-cells.
Sequence similaritiesContains 1 death domain.
Contains 3 TNFR-Cys repeats.
- Information by UniProt
ab8446 has not yet been referenced specifically in any publications.