Product nameHuman DR6 peptide
See all DR6 proteins and peptides
Amino Acid Sequence
SequenceQPEQKASNLIGTYRHC Amino acids 42 to 56 of human DR6 (1)
Amino acids42 to 56
Our Abpromise guarantee covers the use of ab8450 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Blocking - Blocking peptide for Anti-DR6 antibody (ab8417)
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
PBS with 0.1% BSA 0.02% sodium azide pH7.2
- TNFRSF 21
- BM 018
FunctionMay activate NF-kappa-B and promote apoptosis. May activate JNK and be involved in T-cell differentiation. Required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6).
Tissue specificityHighly expressed in heart, brain, placenta, pancreas, lymph node, thymus and prostate. Detected at lower levels in lung, skeletal muscle, kidney, testis, uterus, small intestine, colon, spleen, bone marrow and fetal liver. Very low levels were found in adult liver and peripheral blood leukocytes.
Sequence similaritiesContains 1 death domain.
Contains 4 TNFR-Cys repeats.
- Information by UniProt
ab8450 has not yet been referenced specifically in any publications.