Description

Associated products

Specifications

Our Abpromise guarantee covers the use of ab23029 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-EDD antibody (ab4376)

  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

General Info

  • Alternative names

    • 4432411E13Rik
    • AW549941
    • C77315
    • D030042K14
    • DD5
    • E3 identified by differential display
    • E3 ubiquitin protein ligase, HECT domain containing, 1
    • E3 ubiquitin-protein ligase
    • E3 ubiquitin-protein ligase UBR5
    • EDD
    • EDD 1
    • EDD1
    • FLJ11310
    • HECT domain-containing 1
    • hHYD
    • HYD
    • Hyperplastic discs protein homolog
    • Hyperplastic discs, Drosophila, homolog of
    • KIAA0896
    • MGC57263
    • mKIAA0896
    • Progestin induced protein
    • Progestin-induced protein
    • Rat100
    • Ubiquitin protein ligase
    • Ubiquitin protein ligase E3 component n recognin 5
    • UBR5
    • UBR5_HUMAN
    see all
  • Function

    E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific amino-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (By similarity). May be involved in maturation and/or transcriptional regulation of mRNA. May play a role in control of cell cycle progression. May have tumor suppressor function. Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response. Plays an essential role in extraembryonic development.
  • Tissue specificity

    Widely expressed. Most abundant in testis and expressed at high levels in brain, pituitary and kidney.
  • Pathway

    Protein modification; protein ubiquitination.
  • Sequence similarities

    Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.
    Contains 1 PABC domain.
    Contains 1 UBR-type zinc finger.
  • Post-translational
    modifications

    Phosphorylated upon DNA damage, probably by ATM or ATR.
  • Cellular localization

    Nucleus.
  • Information by UniProt

References

ab23029 has not yet been referenced specifically in any publications.

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