Product nameHuman FLASH peptide
Amino Acid Sequence
SequenceSERFQQLMKLFEKSKC Amino acids 1253 to 1268 of human FLASH (1).
Amino acids1966 to 1981
Our Abpromise guarantee covers the use of ab8455 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Blocking - Blocking peptide for Anti-FLASH antibody (ab8420)
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
PBS with 0.1% BSA 0.02% sodium azide pH7.2
- CASP 8 associated protein 2
FunctionParticipates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF-kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation. Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis. Required for histone gene transcription and progression through S phase.
modificationsPhosphorylated upon DNA damage, probably by ATM or ATR.
Cellular localizationCytoplasm. Nucleus. Localizes to discrete nuclear foci.
- Information by UniProt
ab8455 has not yet been referenced specifically in any publications.