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  1. Link

    human-gnrh-peptide-ab41769.pdf

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Signal Transduction Growth Factors/Hormones Hormones
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Human GnRH peptide (ab41769)

  • Datasheet
Submit a review Submit a question References (2)

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Key features and details

  • Purity: > 95% SDS-PAGE
  • Suitable for: Neutralising, Blocking

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Description

  • Product name

    Human GnRH peptide
    See all GnRH proteins and peptides
  • Purity

    > 95 % SDS-PAGE.

  • Animal free

    No
  • Nature

    Synthetic
    • Species

      Human
    • Sequence

      EHWSYGLRPG
    • Amino acids

      24 to 33

Specifications

Our Abpromise guarantee covers the use of ab41769 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Neutralising

    Blocking

  • Form

    Lyophilized
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20°C. Avoid freeze / thaw cycle.

  • Reconstitution
    Reconstitute with 0.1ml of distilled water to give a final concentration of 0.5 mg/ml.

General Info

  • Alternative names

    • GnRH associated peptide 1
    • GNRH1
    • Gonadotrophin releasing hormone 1
    • GRH
    • HH12
    • LHRH
    • LNRH
    • Luliberin I
    • Luteinizing releasing hormone
    • Lutenizing hormome releasing hormone
    • Progonadoliberin 1
    • Progonadoliberin I
    • Prolactin release inhibiting factor
    see all
  • Relevance

    Gonadotropin releasing hormone (GnRH), also known as luteinizing hormone releasing hormone (LHRH), is a key molecule in the regulation of reproduction in vertebrates. GnRH, a decapeptide, is produced by neurons in the medial basal hypothalamus (MBH) and secreted in a pulsatile manner into the cardiovascular system. The frequency and amplitude of GnRH pulses determine secretion of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary. Higher frequencies (greater than one pulse per hour) stimulate LH secretion while lower frequencies stimulate FSH secretion. The generation of GnRH pulses is effected by numerous stimuli, such as neural, hormonal and environmental. Therefore, behavioral and physiological conditions such as sleep, exercise, and stress can affect the GnRH pulses and cause a disruption of the normal cycle. Recent studies show that GnRH also has a role in mediating cancer. GnRH has been shown to inhibit the growth of human uterine leiomyloma cells by suppressing proliferation and inducing apoptosis. GnRH analogs have been used to treat a wide variety of reproductive cancers, although the side effects of using such compounds are often quite severe.
  • Cellular localization

    Secreted

Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

Datasheets and documents

  • Datasheet download

    Download

References (2)

Publishing research using ab41769? Please let us know so that we can cite the reference in this datasheet.

ab41769 has been referenced in 2 publications.

  • Hatef A & Unniappan S Gonadotropin-releasing hormone, kisspeptin, and gonadal steroids directly modulate nucleobindin-2/nesfatin-1 in murine hypothalamic gonadotropin-releasing hormone neurons and gonadotropes. Biol Reprod 96:635-651 (2017). PubMed: 28339602
  • Higa-Nakamine S  et al. Selective cleavage of ErbB4 by G-protein-coupled gonadotropin-releasing hormone receptor in cultured hypothalamic neurons. J Cell Physiol 227:2492-501 (2012). PubMed: 21898395

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