Human GnRH peptide (ab41769)
Key features and details
- Purity: > 95% SDS-PAGE
- Suitable for: Neutralising, Blocking
Description
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Product name
Human GnRH peptide
See all GnRH proteins and peptides -
Purity
> 95 % SDS-PAGE. -
Animal free
No -
Nature
Synthetic -
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Species
Human -
Sequence
EHWSYGLRPG -
Amino acids
24 to 33
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Specifications
Our Abpromise guarantee covers the use of ab41769 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Applications
Neutralising
Blocking
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Form
Lyophilized -
Concentration information loading...
Preparation and Storage
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Stability and Storage
Shipped at 4°C. Store at -20°C. Avoid freeze / thaw cycle.
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ReconstitutionReconstitute with 0.1ml of distilled water to give a final concentration of 0.5 mg/ml.
General Info
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Alternative names
- GnRH associated peptide 1
- GNRH1
- Gonadotrophin releasing hormone 1
see all -
Relevance
Gonadotropin releasing hormone (GnRH), also known as luteinizing hormone releasing hormone (LHRH), is a key molecule in the regulation of reproduction in vertebrates. GnRH, a decapeptide, is produced by neurons in the medial basal hypothalamus (MBH) and secreted in a pulsatile manner into the cardiovascular system. The frequency and amplitude of GnRH pulses determine secretion of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary. Higher frequencies (greater than one pulse per hour) stimulate LH secretion while lower frequencies stimulate FSH secretion. The generation of GnRH pulses is effected by numerous stimuli, such as neural, hormonal and environmental. Therefore, behavioral and physiological conditions such as sleep, exercise, and stress can affect the GnRH pulses and cause a disruption of the normal cycle. Recent studies show that GnRH also has a role in mediating cancer. GnRH has been shown to inhibit the growth of human uterine leiomyloma cells by suppressing proliferation and inducing apoptosis. GnRH analogs have been used to treat a wide variety of reproductive cancers, although the side effects of using such compounds are often quite severe. -
Cellular localization
Secreted
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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Datasheet download
References (2)
ab41769 has been referenced in 2 publications.
- Hatef A & Unniappan S Gonadotropin-releasing hormone, kisspeptin, and gonadal steroids directly modulate nucleobindin-2/nesfatin-1 in murine hypothalamic gonadotropin-releasing hormone neurons and gonadotropes. Biol Reprod 96:635-651 (2017). PubMed: 28339602
- Higa-Nakamine S et al. Selective cleavage of ErbB4 by G-protein-coupled gonadotropin-releasing hormone receptor in cultured hypothalamic neurons. J Cell Physiol 227:2492-501 (2012). PubMed: 21898395