Description

Associated products

Specifications

Our Abpromise guarantee covers the use of ab99223 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-HSD11B1 antibody (ab83522)

  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

General Info

  • Alternative names

    • 11 beta HSD 1
    • 11 beta HSD1
    • 11 beta hydroxysteroid dehydrogenase 1
    • 11 DH
    • 11-beta hydroxysteroid dehydrogenase, type 1
    • 11-beta-HSD1
    • 11-beta-hydroxysteroid dehydrogenase 1
    • 11-DH
    • 11DH
    • Corticosteroid 11 beta dehydrogenase isozyme 1
    • Corticosteroid 11-beta-dehydrogenase isozyme 1
    • CORTRD2
    • DHI1_HUMAN
    • HDL
    • HSD 11
    • HSD11
    • HSD11B
    • HSD11B1
    • HSD11L
    • Hydroxysteroid (11 beta) dehydrogenase
    • Hydroxysteroid (11 beta) dehydrogenase 1
    • MGC13539
    • SDR26C1
    • short chain dehydrogenase/reductase family 26C, member 1
    see all
  • Function

    Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7-ketocholesterol to 7-beta-hydroxycholesterol.
  • Tissue specificity

    Widely expressed. Highest expression in liver.
  • Involvement in disease

    Defects in HSD11B1 are a cause of cortisone reductase deficiency (CRD) [MIM:604931]. In CRD, activation of cortisone to cortisol does not occur, resulting in adrenocorticotropin-mediated androgen excess and a phenotype resembling polycystic ovary syndrome (PCOS).
  • Sequence similarities

    Belongs to the short-chain dehydrogenases/reductases (SDR) family.
  • Post-translational
    modifications

    Glycosylated.
  • Cellular localization

    Endoplasmic reticulum membrane.
  • Information by UniProt

References

ab99223 has not yet been referenced specifically in any publications.

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