Product nameHuman HuR / ELAVL1 peptide
See all HuR / ELAVL1 proteins and peptides
Our Abpromise guarantee covers the use of ab28843 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
- First try to dissolve a small amount of peptide in either water or buffer. The more charged residues on a peptide, the more soluble it is in aqueous solutions.
- If the peptide doesn’t dissolve try an organic solvent e.g. DMSO, then dilute using water or buffer.
- Consider that any solvent used must be compatible with your assay. If a peptide does not dissolve and you need to recover it, lyophilise to remove the solvent.
- Gentle warming and sonication can effectively aid peptide solubilisation. If the solution is cloudy or has gelled the peptide may be in suspension rather than solubilised.
- Peptides containing cysteine are easily oxidised, so should be prepared in solution just prior to use.
Concentration information loading...
Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Information available upon request.
- ELAV (embryonic lethal abnormal vision Drosophila) like 1
- ELAV (embryonic lethal, abnormal vision, Drosophila) like 1 (Hu antigen R)
- ELAV like 1
FunctionInvolved in 3'-UTR ARE-mediated MYC stabilization. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, HUR binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA and AUUUUUA motifs.
Sequence similaritiesBelongs to the RRM elav family.
Contains 3 RRM (RNA recognition motif) domains.
modificationsMethylated at Arg-217 by CARM1 in macrophages in response to LPS challenge.
- Information by UniProt
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab28843 has not yet been referenced specifically in any publications.