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  1. Link

    human-il-23-peptide-ab91437.pdf

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Immunology Innate Immunity Cytokines Interleukins
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Human IL-23 peptide (ab91437)

  • Datasheet
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Key features and details

  • Suitable for: Blocking

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Description

  • Product name

    Human IL-23 peptide
    See all IL-23 proteins and peptides
  • Purity

    70 - 90% by HPLC.

  • Animal free

    No
  • Nature

    Synthetic
    • Species

      Human

Associated products

    Specifications

    Our Abpromise guarantee covers the use of ab91437 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • Applications

      Blocking

    • Form

      Liquid
    • Additional notes

      - First try to dissolve a small amount of peptide in either water or buffer. The more charged residues on a peptide, the more soluble it is in aqueous solutions.
      - If the peptide doesn’t dissolve try an organic solvent e.g. DMSO, then dilute using water or buffer.
      - Consider that any solvent used must be compatible with your assay. If a peptide does not dissolve and you need to recover it, lyophilise to remove the solvent.
      - Gentle warming and sonication can effectively aid peptide solubilisation. If the solution is cloudy or has gelled the peptide may be in suspension rather than solubilised.
      - Peptides containing cysteine are easily oxidised, so should be prepared in solution just prior to use.

    • Concentration information loading...

    Preparation and Storage

    • Stability and Storage

      Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

      Information available upon request.

    General Info

    • Alternative names

      • IL 23
      • IL 23 A
      • IL 23 subunit alpha
      • IL 23A
      • IL 23p19
      • IL-23 subunit alpha
      • IL-23-A
      • IL-23p19
      • IL12B
      • IL23
      • Il23a
      • IL23A_HUMAN
      • IL23P19
      • interleukin 12B
      • Interleukin 23 alpha subunit p19
      • Interleukin 23 p19 subunit
      • interleukin 23 subunit alpha
      • interleukin 23 subunit p19
      • interleukin six, G CSF related factor
      • Interleukin-23 subunit alpha
      • Interleukin-23 subunit p19
      • JKA3 induced upon T cell activation
      • MGC79388
      • P19
      • SGRF
      see all
    • Function

      Associates with IL12B to form the IL-23 interleukin, an heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to an heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.
    • Tissue specificity

      Secreted by activated dendritic and phagocytic cells and keratinocytes. Also expressed by dermal Langerhans cells (at protein level).
    • Sequence similarities

      Belongs to the IL-6 superfamily.
    • Developmental stage

      Expressed by newborns dendritic cells.
    • Cellular localization

      Secreted. Secreted upon association with IL12B.
    • Target information above from: UniProt accession Q9NPF7 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    Datasheets and documents

    • Datasheet
  • References (0)

    Publishing research using ab91437? Please let us know so that we can cite the reference in this datasheet.

    ab91437 has not yet been referenced specifically in any publications.

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