Description

  • Product name

    Human Integrin beta 4 (phospho Y1526) peptide
    See all Integrin beta 4 proteins and peptides
  • Biological activity

    This peptide is found in all three Integrin beta 4 isoforms and is highly conserved in rat and mouse Integrin beta 4.
  • Animal free

    No
  • Nature

    Synthetic
    • Species

      Human
    • Modifications

      phospho Y1526

Associated products

Specifications

Our Abpromise guarantee covers the use of ab42719 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-Integrin beta 4 (phospho Y1526) antibody (ab29044)

    ELISA

  • Form

    Liquid
  • Additional notes

    The concentration of this peptide is specified on the datasheet.This peptide is found in all three Integrin beta 4 isoforms and is highly conserved in rat and mouse Integrin beta 4.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: 0.05% Sodium azide
    Constituent: PBS

General Info

  • Alternative names

    • CD 104
    • CD104
    • CD104 antigen
    • gp150
    • Integrin beta 4 subunit
    • Integrin beta-4
    • ITB4_HUMAN
    • ITG B4
    • ITGB 4
    • Itgb4
    see all
  • Function

    Integrin alpha-6/beta-4 is a receptor for laminin. It plays a critical structural role in the hemidesmosome of epithelial cells.
  • Tissue specificity

    Integrin alpha-6/beta-4 is predominantly expressed by epithelia. Isoform beta-4D is also expressed in colon and placenta. Isoform beta-4E is also expressed in epidermis, lung, duodenum, heart, spleen and stomach.
  • Involvement in disease

    Defects in ITGB4 are a cause of epidermolysis bullosa letalis with pyloric atresia (EB-PA) [MIM:226730]; also known as junctional epidermolysis bullosa with pyloric atresia (PA-JEB) or aplasia cutis congenita with gastrointestinal atresia. EB-PA is an autosomal recessive, frequently lethal, epidermolysis bullosa with variable involvement of skin, nails, mucosa, and with variable effects on the digestive system. It is characterized by mucocutaneous fragility, aplasia cutis congenita, and gastrointestinal atresia, which most commonly affects the pylorus. Pyloric atresia is a primary manifestation rather than a scarring process secondary to epidermolysis bullosa.
    Defects in ITGB4 are a cause of generalized atrophic benign epidermolysis bullosa (GABEB) [MIM:226650]. GABEB is a non-lethal, adult form of junctional epidermolysis bullosa characterized by life-long blistering of the skin, associated with hair and tooth abnormalities.
  • Sequence similarities

    Belongs to the integrin beta chain family.
    Contains 1 Calx-beta domain.
    Contains 4 fibronectin type-III domains.
    Contains 1 PSI domain.
    Contains 1 VWFA domain.
  • Domain

    The fibronectin type-III-like domains bind BPAG1 and plectin and probably also recruit BP230.
  • Cellular localization

    Membrane.
  • Information by UniProt

References

ab42719 has not yet been referenced specifically in any publications.

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