Overview

Description

  • Nature
    Synthetic
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      C-QRSFFRENQQITV
    • Amino acids
      414 to 426

Associated products

Specifications

Our Abpromise guarantee covers the use of ab22947 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-IRF8 antibody (ab3428)

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

General Info

  • Alternative names
    • H ICSBP
    • H-ICSBP
    • HGNC:5358
    • HICSBP
    • ICSBP
    • ICSBP 1
    • ICSBP1
    • Interferon consensus sequence binding protein
    • Interferon consensus sequence binding protein 1
    • Interferon consensus sequence-binding protein
    • Interferon regulatory factor 8
    • IRF 8
    • IRF-8
    • Irf8
    • IRF8_HUMAN
    • MYLS
    see all
  • Function
    Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)). Plays a negative regulatory role in cells of the immune system.
  • Tissue specificity
    Predominantly in lymphoid tissues.
  • Sequence similarities
    Belongs to the IRF family.
    Contains 1 IRF tryptophan pentad repeat DNA-binding domain.
  • Post-translational
    modifications
    Ubiquitinated. Ubiquitination by TRIM21 in macrophages, a process that is strongly increased upon interferon gamma stimulation, leds to the enhanced transcriptional activity of target cytokine genes.
  • Cellular localization
    Nucleus.
  • Information by UniProt

References

ab22947 has not yet been referenced specifically in any publications.

Publishing research using ab22947? Please let us know so that we can cite the reference in this datasheet.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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