Human IRF8 peptide (ab22947)

Our Abpromise guarantee covers the use of ab22947 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Stability and Storage

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Alternative names
- H ICSBP
- H-ICSBP
- HGNC:5358
- HICSBP
- ICSBP
- ICSBP 1
- ICSBP1
- Interferon consensus sequence binding protein
- Interferon consensus sequence binding protein 1
- Interferon consensus sequence-binding protein
- Interferon regulatory factor 8
- IRF 8
- IRF-8
- Irf8
- IRF8_HUMAN
- MYLS
see all
Function

Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)). Plays a negative regulatory role in cells of the immune system.
Tissue specificity

Predominantly in lymphoid tissues.
Sequence similarities

Belongs to the IRF family.
Contains 1 IRF tryptophan pentad repeat DNA-binding domain.
Post-translational
modifications

Ubiquitinated. Ubiquitination by TRIM21 in macrophages, a process that is strongly increased upon interferon gamma stimulation, leds to the enhanced transcriptional activity of target cytokine genes.
Cellular localization

Nucleus.
Target information above from: UniProt accession Q02556 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt

ab22947 has not yet been referenced specifically in any publications.

Publishing research using ab22947? Please let us know so that we can cite the reference in this datasheet.

Customer reviews and Q&As

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"