Human IRF8 peptide (ab22947)
- Datasheet
- References
- Protocols
Description
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Product name
Human IRF8 peptide
See all IRF8 proteins and peptides -
Animal free
No -
Nature
Synthetic -
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Species
Human -
Sequence
C-QRSFFRENQQITV -
Amino acids
414 to 426
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Associated products
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Corresponding Antibody
Specifications
Our Abpromise guarantee covers the use of ab22947 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Applications
Blocking - Blocking peptide for Anti-IRF8 antibody (ab3428)
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Form
Liquid -
Concentration information loading...
Preparation and Storage
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Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
General Info
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Alternative names
- H ICSBP
- H-ICSBP
- HGNC:5358
see all -
Function
Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)). Plays a negative regulatory role in cells of the immune system. -
Tissue specificity
Predominantly in lymphoid tissues. -
Sequence similarities
Belongs to the IRF family.
Contains 1 IRF tryptophan pentad repeat DNA-binding domain. -
Post-translational
modificationsUbiquitinated. Ubiquitination by TRIM21 in macrophages, a process that is strongly increased upon interferon gamma stimulation, leds to the enhanced transcriptional activity of target cytokine genes. -
Cellular localization
Nucleus. - Information by UniProt
Datasheets and documents
References
ab22947 has not yet been referenced specifically in any publications.
