• Nature
  • Amino Acid Sequence
    • Species

Associated products


Our Abpromise guarantee covers the use of ab105483 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Purity
    70 - 90% by HPLC.

  • Form
  • Additional notes

    - First try to dissolve a small amount of peptide in either water or buffer. The more charged residues on a peptide, the more soluble it is in aqueous solutions.
    - If the peptide doesn’t dissolve try an organic solvent e.g. DMSO, then dilute using water or buffer.
    - Consider that any solvent used must be compatible with your assay. If a peptide does not dissolve and you need to recover it, lyophilise to remove the solvent.
    - Gentle warming and sonication can effectively aid peptide solubilisation. If the solution is cloudy or has gelled the peptide may be in suspension rather than solubilised.
    - Peptides containing cysteine are easily oxidised, so should be prepared in solution just prior to use.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Information available upon request.

General Info

  • Alternative names
    • IFI1
    • Iigp3
    • Iipg3
    • Immunity related GTPase family M protein 1
    • Immunity related GTPase family, M
    • Immunity-related GTPase family M protein
    • Immunity-related GTPase family M protein 1
    • Interferon inducible protein 1
    • Interferon-inducible protein 1
    • Irgm
    • IRGM1
    • LPS-stimulated RAW 264.7 macrophage protein 47 homolog
    • LRG 47
    • LRG-47
    • LRG-47-like protein
    • LRG47
    • MGC149263
    • MGC149264
    see all
  • Function
    Putative GTPase which is required for clearance of acute protozoan and bacterial infections. Functions in innate immune response probably through regulation of autophagy. May regulate proinflammatory cytokine production and prevent endotoxemia upon infection. May also play a role in macrophages adhesion and motility.
  • Tissue specificity
    Widely expressed (at protein level). Expressed in several tissues including colon, small bowel and peripheral blood leukocytes.
  • Involvement in disease
    Defects in IRGM are the cause of susceptibility to inflammatory bowel disease type 19 (IBD19) [MIM:612278]. A chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints.
  • Sequence similarities
    Belongs to the interferon-inducible GTPase family.
  • Cellular localization
    Golgi apparatus membrane. Cell membrane. Cytoplasmic vesicle > phagosome membrane. Cytoplasmic vesicle > autophagosome membrane. Cell projection > phagocytic cup. Behaves like an integral membrane protein (By similarity). Recruited to the plasma membrane around forming phagocytic cups, it remains associated with maturing autophagosomes (By similarity). Preferentially associated with cis- and medial-Golgi.
  • Information by UniProt


ab105483 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

Voici le protocole utilisé par le laboratoire : - 10µg de lysat par puit (under reducing conditions), - transfert sur membrane nitrocellulose (1 heure, 90V), - blocage avec 5% de BSA (1 heure, température ambiante), - incubation du primaire...

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Je suis désolé d'apprendre que ab93901 ne vous donne pas de bons résultats pour la détection de IRGM endogène. Le laboratoire et moi-même aimerions avoir plus d'informations sur le protocole que vous avez utilisé avec cet anticorps. Veuillez tr...

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