Description

  • Product name

    Human Lipin 2/LPIN2 peptide
  • Animal free

    No
  • Nature

    Synthetic
    • Species

      Human
    • Sequence

      (C)YWRDPIPEVDLDDLS
    • Amino acids

      882 to 896

Specifications

Our Abpromise guarantee covers the use of ab45703 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking

  • Form

    Lyophilised
  • Additional notes

    Protein previously labeled as Lipin 2.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20°C. Avoid freeze / thaw cycle.

  • Reconstitution
    Please reconstitute this product in 100ul sterile water.

General Info

  • Alternative names

    • KIAA0249
    • Lipin-2
    • Lipin2
    • LPIN 2
    • LPIN2
    • LPIN2_HUMAN
    • OTTHUMP00000162242
    • Phosphatidate phosphatase LPIN2
    see all
  • Function

    Plays important roles in controlling the metabolism of fatty acids at differents levels. Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the reticulum endoplasmic membrane. Acts also as a nuclear transcriptional coactivator for PPARGC1A to modulate lipid metabolism.
  • Tissue specificity

    Expressed in liver, lung, kidney, placenta, spleen, thymus, lymph node, prostate, testes, small intestine, and colon.
  • Involvement in disease

    Defects in LPIN2 are the cause of Majeed syndrome (MAJEEDS) [MIM:609628]. An autosomal recessive syndrome characterized by chronic recurrent multifocal osteomyelitis that is of early onset with a lifelong course, congenital dyserythropoietic anemia that presents as hypochromic, microcytic anemia during the first year of life and ranges from mild to transfusion-dependent, and transient inflammatory dermatosis, often manifesting as Sweet syndrome (neutrophilic skin infiltration).
  • Sequence similarities

    Belongs to the lipin family.
  • Domain

    Contains 1 Asp-Xaa-Asp-Xaa-Thr (DXDXT) motif, a catalytic motif known to be essential for phosphatidate phosphatase activity.
    Contains one Leu-Xaa-Xaa-Ile-Leu (LXXIL) motif, a motif known to be a transcriptional binding motif.
  • Cellular localization

    Nucleus. Cytoplasm > cytosol. Endoplasmic reticulum membrane. Translocates to endoplasmic reticulum membrane with increasing levels of oleate.
  • Information by UniProt

References

ab45703 has not yet been referenced specifically in any publications.

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