Description

  • Product name

    Human Mad2L2/REV7 peptide
  • Biological activity

    This product can be used as the blocking peptide for ab3630.
  • Animal free

    No
  • Nature

    Synthetic
    • Species

      Human
    • Sequence

      TLTRQDLNFGQV (amino acids 1-14) of human Mad2L2.
    • Amino acids

      3 to 14

Specifications

Our Abpromise guarantee covers the use of ab11254 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Form

    Liquid
  • Additional notes

    This product can be used as the blocking peptide for ab3630.

     This product was previously labelled as Mad2L2

     

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: 0.02% Sodium azide
    Constituent: PBS

General Info

  • Alternative names

    • Homolog of REV7 S cerevisiae
    • hREV7
    • MAD2 (mitotic arrest deficient yeast, homolog) like 2
    • MAD2 homolog
    • MAD2 like 2
    • MAD2 mitotic arrest deficient like 2
    • MAD2-like protein 2
    • MAD2B
    • Mad2l2
    • MD2L2_HUMAN
    • Mitotic Arrest Deficient 2 L2
    • Mitotic arrest deficient 2-like protein 2
    • Mitotic arrest deficient homolog like 2
    • Mitotic arrest deficient like 2 (yeast)
    • Mitotic arrest deficient yeast homolog
    • Mitotic spindle assembly checkpoint protein MAD2B
    • Polymerase (DNA directed) zeta 2 accessory subunit
    • POLZ2
    • REV 7
    • REV7
    • REV7 homolog
    • Weakly similar to Mitotic MAD2 protein (S cerevisiae)
    see all
  • Function

    Adapter protein able to interact with different proteins and involved in different biological processes. Mediates the interaction between the error-prone DNA polymerase zeta catalytic subunit REV3L and the inserter polymerase REV1, thereby mediating the second polymerase switching in translesion DNA synthesis. Translesion DNA synthesis releases the replication blockade of replicative polymerases, stalled in presence of DNA lesions. May also regulate another aspect of cellular response to DNA damage through regulation of the JNK-mediated phosphorylation and activation of the transcriptional activator ELK1. Inhibits the FZR1- and probably CDC20-mediated activation of the anaphase promoting complex APC thereby regulating progression through the cell cycle. Regulates TCF7L2-mediated gene transcription and may play a role in epithelial-mesenchymal transdifferentiation.
  • Tissue specificity

    Ubiquitously expressed.
  • Sequence similarities

    Contains 1 HORMA domain.
  • Cellular localization

    Nucleus. Cytoplasm > cytoskeleton > spindle. Cytoplasm.
  • Information by UniProt

References

ab11254 has not yet been referenced specifically in any publications.

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