• Nature
  • Amino Acid Sequence
    • Species
    • Sequence
    • Amino acids
      2 to 14

Associated products


Our Abpromise guarantee covers the use of ab23050 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-MDA5 antibody (ab4544)

  • Form
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

General Info

  • Alternative names
    • CADM-140 autoantigen
    • Clinically amyopathic dermatomyositis autoantigen 140 kDa
    • DEAD/H (Asp Glu Ala Asp/His) box polypeptide
    • DEAD/H box polypeptide
    • Helicard
    • Helicase with 2 CARD domains
    • Hlcd
    • IDDM 19
    • IDDM19
    • IFIH 1
    • Ifih1
    • Interferon induced helicase C domain containing protein 1
    • interferon induced with helicase C domain 1
    • Interferon induced with helicase C domain protein 1
    • Interferon-induced helicase C domain-containing protein 1
    • Interferon-induced with helicase C domain protein 1
    • MDA 5
    • MDA-5
    • Melanoma differentiation associated protein 5
    • Melanoma differentiation-associated gene 5
    • Melanoma differentiation-associated protein 5
    • MGC133047
    • Murabutide down regulated protein
    • Murabutide down-regulated protein
    • RH 116
    • RH116
    • RIG I like receptor 2
    • RLR 2
    • RNA helicase DEAD box protein 116
    • RNA helicase-DEAD box protein 116
    see all
  • Function
    RNA helicase that, through its ATP-dependent unwinding of RNA, may function to promote message degradation by specific RNases. Seems to have growth suppressive properties. Involved in innate immune defense against viruses. Upon interaction with intracellular dsRNA produced during viral replication, triggers a transduction cascade involving MAVS/IPS1, which results in the activation of NF-kappa-B, IRF3 and IRF7 and the induction of the expression of antiviral cytokines such as IFN-beta and RANTES (CCL5). ATPase activity is specifically induced by dsRNA. Essential for the production of interferons in response to picornaviruses.
  • Tissue specificity
    Widely expressed, at a low level. Expression is detected at slightly highest levels in placenta, pancreas and spleen and at barely levels in detectable brain, testis and lung.
  • Involvement in disease
    Genetic variation in IFIH1 is associated with diabetes mellitus insulin-dependent type 19 (IDDM19) [MIM:610155]. A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical fetaures are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.
    Note=IFIH1 is the CADM-140 autoantigen, involved in clinically amyopathic dermatomyositis (CADM). This is a chronic inflammatory disorder that shows typical skin manifestations of dermatomyositis but has no or little evidence of clinical myositis. Anti-CADM-140 antibodies appear to be specific to dermatomyositis, especially CADM. Patients with anti-CADM-140 antibodies frequently develop life-threatening acute progressive interstitial lung disease (ILD).
  • Sequence similarities
    Belongs to the helicase family.
    Contains 2 CARD domains.
    Contains 1 helicase ATP-binding domain.
    Contains 1 helicase C-terminal domain.
  • Post-translational
    During apoptosis, processed into 3 cleavage products. The helicase-containing fragment, once liberated from the CARD domains, translocate from the cytoplasm to the nucleus. The processed protein significantly sensitizes cells to DNA degradation.
  • Cellular localization
    Cytoplasm. Nucleus. May be found in the nucleus, during apoptosis.
  • Information by UniProt


ab23050 has not yet been referenced specifically in any publications.

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