Product nameHuman Metnase peptide
See all Metnase proteins and peptides
Amino Acid Sequence
Amino acids658 to 671
Our Abpromise guarantee covers the use of ab22960 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Blocking - Blocking peptide for Anti-Metnase antibody (ab3823)
Previously labelled as SETMAR.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
- Histone lysine N methyltransferase
- Histone lysine N methyltransferase SETMAR
- Hsmar 1
FunctionHistone methyltransferase that methylates 'Lys-4' and 'Lys-36' of histone H3, 2 specific tags for epigenetic transcriptional activation. Specifically mediates dimethylation of H3 'Lys-36'. Has sequence-specific DNA-binding activity and recognizes the 19-mer core of the 5'-terminal inverted repeats (TIRs) of the Hsmar1 element. Has DNA nicking activity. Has in vivo end joining activity and may mediate genomic integration of foreign DNA.
Tissue specificityWidely expressed, with highest expression in placenta and ovary and lowest expression in skeletal muscle.
Sequence similaritiesIn the N-terminal section; belongs to the histone-lysine methyltransferase family.
In the C-terminal section; belongs to the mariner transposase family.
Contains 1 post-SET domain.
Contains 1 pre-SET domain.
Contains 1 SET domain.
DomainThe mariner transposase Hsmar1 region mediates DNA-binding. It has no transposase activity because the active site contains an Asn in position 610 instead of a Asp residue.
Cellular localizationNucleus. Chromosome.
- Information by UniProt
ab22960 has not yet been referenced specifically in any publications.