Key features and details
- Rabbit polyclonal to Human Milk Fat Globule 1
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Product nameAnti-Human Milk Fat Globule 1 antibody
See all Milk Fat Globule 1 primary antibodies
DescriptionRabbit polyclonal to Human Milk Fat Globule 1
Tested applicationsSuitable for: WBmore details
Species reactivityReacts with: Human
Predicted to work with: Rhesus monkey
Recombinant full length protein corresponding to Human Milk Fat Globule 1 aa 1-387.
MPRPRLLAALCGALLCAPSLLVALDICSKNPCHNGGLCEEISQEVRGDVF PSYTCTCLKGYAGNHCETKCVEPLGMENGNIANSQIAASSVRVTFLGLQH WVPELARLNRAGMVNAWTPSSNDDNPWIQVNLLRRMWVTGVVTQGASRLA SHEYLKAFKVAYSLNGHEFDFIHDVNKKHKEFVGNWNKNAVHVNLFETPV EAQYVRLYPTSCHTACTLRFELLGCELNGCANPLGLKNNSIPDKQITASS SYKTWGLHLFSWNPSYARLDKQGNFNAWVAGSYGNDQWLQVDLGSSKEVT GIITQGARNFGSVQFVASYKVAYSNDSANWTEYQDPRTGSSKIFPGNWDN HSHKKNLFETPILARYVRILPVAWHNRIALRLELLGC
- Human Milk Fat Globule 1 transfected 293T cell lysate
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
Storage bufferpH: 7.4
Constituent: 100% PBS
Concentration information loading...
PurityProtein A purified
Our Abpromise guarantee covers the use of ab168733 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||Use a concentration of 1 µg/ml. Predicted molecular weight: 43 kDa.|
FunctionPlays an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing. Promotes VEGF-dependent neovascularization (By similarity). Contributes to phagocytic removal of apoptotic cells in many tissues. Specific ligand for the alpha-v/beta-3 and alpha-v/beta-5 receptors. Also binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner. Zona pellucida-binding protein which may play a role in gamete interaction. Binds specifically to rotavirus and inhibits its replication.
Medin is the main constituent of aortic medial amyloid.
Tissue specificityMammary epithelial cell surfaces and aortic media. Overexpressed in several carcinomas.
Sequence similaritiesContains 1 EGF-like domain.
Contains 2 F5/8 type C domains.
modificationsMedin has a ragged N-terminus with minor species starting at Pro-264 and Gly-273.
Cellular localizationMembrane. Secreted.
- Information by UniProt
- BA46 antibody
- Breast epithelial antigen BA46 antibody
- EDIL1 antibody
All lanes : Anti-Human Milk Fat Globule 1 antibody (ab168733) at 1 µg/ml
Lane 1 : Human Milk Fat Globule 1 transfected 293T cell lysate
Lane 2 : Non-transfected 293T cell lysate
Lysates/proteins at 15 µl per lane.
All lanes : Goat Anti-Rabbit IgG (H+L), Peroxidase Conjugated secondary antibody at 1/2500 dilution
Predicted band size: 43 kDa
ab168733 has been referenced in 2 publications.
- Yang Y et al. Reduction in milk fat globule-EGF factor 8 inhibits triple-negative breast cancer cell viability and migration. Oncol Lett 17:3457-3465 (2019). PubMed: 30867784
- Wang JH et al. Anti-HER2 scFv-Directed Extracellular Vesicle-Mediated mRNA-Based Gene Delivery Inhibits Growth of HER2-Positive Human Breast Tumor Xenografts by Prodrug Activation. Mol Cancer Ther 17:1133-1142 (2018). PubMed: 29483213