Description

  • Product name

    Human Myosin 18B peptide
  • Animal free

    No
  • Nature

    Synthetic
    • Species

      Human
    • Sequence

      C-DDVASIMKKYLQK
    • Amino acids

      2555 to 2567

Specifications

Our Abpromise guarantee covers the use of ab45499 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking

  • Form

    Lyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20°C. Avoid freeze / thaw cycle.

  • Reconstitution
    Reconstitute in 100ul sterile water.

General Info

  • Alternative names

    • BK125H2.1
    • DKFZp434C2422
    • DKFZp779C1668
    • MY18B_HUMAN
    • MYO18B
    • myosin 18B
    • myosin XVIIIB
    • Myosin-XVIIIb
    see all
  • Function

    May be involved in intracellular trafficking of the muscle cell when in the cytoplasm, whereas entering the nucleus, may be involved in the regulation of muscle specific genes. May play a role in the control of tumor development and progression; restored MYO18B expression in lung cancer cells suppresses anchorage-independent growth.
  • Tissue specificity

    Selectively expressed in cardiac and skeletal muscles. Weakly expressed in testis, pancreas, placenta, prostate, lung and thymus.
  • Sequence similarities

    Contains 1 IQ domain.
    Contains 1 myosin head-like domain.
  • Developmental stage

    Reaches an expression peak in the third day after induction and remains at similar level during successive myotubule maturation.
  • Cellular localization

    Cytoplasm. Nucleus. Cytoplasm > myofibril > sarcomere. Punctate pattern in undifferentiated myoblasts. Nuclear, on primary cardiomyocytes and adult muscle. A partial sarcomeric location was found in some cardiomyocytes.
  • Information by UniProt

References

ab45499 has not yet been referenced specifically in any publications.

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