Product nameHuman N WASP (phospho Y256) peptide
See all N WASP proteins and peptides
Amino Acid Sequence
Our Abpromise guarantee covers the use of ab42793 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Biological activityHuman WASP sequence has a two amino acid difference in the region surrounding Tyrosine 291.
Blocking - Blocking peptide for Anti-N WASP (phospho Y256) antibody (ab23395)
Phosphorylation at serine and tyrosine residues regulates the activity of both proteins. WASP is tyrosine phosphorylated at tyrosine 291 after antigen receptor activation in B-cells and collagen stimulation of platelets. Phosphorylation of the analogous site in N WASP (Tyr-256) stimulates its activity, reduces nuclear N WASP, and is required for neurite extension.Human WASP sequence has a two amino acid difference in the region surrounding Tyrosine 291.
Concentration information loading...
Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Preservative: 0.05% Sodium azide
FunctionRegulates actin polymerization by stimulating the actin-nucleating activity of the Arp2/3 complex. Binds to HSF1/HSTF1 and forms a complex on heat shock promoter elements (HSE) that negatively regulates HSP90 expression.
Sequence similaritiesContains 1 CRIB domain.
Contains 1 WH1 domain.
Contains 2 WH2 domains.
Cellular localizationCytoplasm > cytoskeleton. Nucleus. Preferentially localized in the cytoplasm when phosphorylated and in the nucleus when unphosphorylated.
- Information by UniProt
ab42793 has not yet been referenced specifically in any publications.