Description

  • Product name

    Human Nogo A peptide
  • Animal free

    No
  • Nature

    Synthetic
    • Species

      Human

Associated products

Specifications

Our Abpromise guarantee covers the use of ab234893 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-Nogo A antibody (ab62024)

  • Form

    Lyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20°C. Avoid freeze / thaw cycle.

General Info

  • Alternative names

    • ASY
    • Foocen
    • Human NogoA
    • My043 protein
    • Nbla00271
    • Nbla10545
    • neurite growth inhibitor 220
    • Neurite outgrowth inhibitor
    • Neuroendocrine-specific protein
    • Neuroendocrine-specific protein C homolog
    • NI220/250
    • NOGO
    • Nogo A
    • Nogo protein
    • NOGO-A
    • Nogo-B
    • Nogo-C
    • NSP
    • NSP-CL
    • Reticulon 4
    • reticulon 5
    • Reticulon-4
    • Reticulon-5
    • RTN 4
    • RTN 4A
    • RTN xL
    • RTN-x
    • Rtn4
    • RTN4-A
    • RTN4-B1
    • RTN4-B2
    • RTN4-C
    • RTN4_HUMAN
    see all
  • Function

    Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS. Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex (By similarity). Isoform 2 reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration. Isoform 2 and isoform 3 inhibit BACE1 activity and amyloid precursor protein processing.
  • Tissue specificity

    Isoform 1 is specifically expressed in brain and testis and weakly in heart and skeletal muscle. Isoform 2 is widely expressed except for the liver. Isoform 3 is expressed in brain, skeletal muscle and adipocytes. Isoform 4 is testis-specific.
  • Sequence similarities

    Contains 1 reticulon domain.
  • Domain

    Three regions, residues 59-172, 544-725 and the loop 66 amino acids, between the two transmembrane domains, known as Nogo-66 loop, appear to be responsible for the inhibitory effect on neurite outgrowth and the spreading of neurons. This Nogo-66 loop, mediates also the binding of RTN4 to its receptor.
  • Cellular localization

    Endoplasmic reticulum membrane. Anchored to the membrane of the endoplasmic reticulum through 2 putative transmembrane domains.
  • Information by UniProt

References

ab234893 has not yet been referenced specifically in any publications.

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