Product nameHuman Noxa peptide
See all Noxa proteins and peptides
Amino Acid Sequence
Our Abpromise guarantee covers the use of ab39823 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Blocking - Blocking peptide for Anti-Noxa antibody (ab36833)
Concentration information loading...
Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Preservative: 0.02% Sodium Azide
Constituents: 0.1% BSA, PBS, pH 7.2
- Adult T cell leukemia derived PMA responsive
FunctionPromotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1 (By similarity). Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1.
Tissue specificityHighly expressed in adult T-cell leukemia cell line.
Sequence similaritiesBelongs to the PMAIP1 family.
DomainThe BH3 motif is essential for pro-apoptotic activity.
- Information by UniProt
ab39823 has not yet been referenced specifically in any publications.