Product nameHuman Plexin A1 peptide
See all Plexin A1 proteins and peptides
Amino Acid Sequence
SequenceThis sequence is highly conserved in Rat and Mouse Plexin A1, and has low homology to other Plexin family members.
Our Abpromise guarantee covers the use of ab42757 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Blocking - Blocking peptide for Anti-Plexin A1 antibody (ab23391)
Concentration information loading...
Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Preservative: 0.05% Sodium azide
- NOV/plexin A1 protein
RelevanceFunction: Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm. Tissue specificity: Detected in fetal brain, lung, liver and kidney. Similarity: Belongs to the plexin family. Contains 4 IPT/TIG domains. Contains 1 Sema domain.
Cellular localizationCell Membrane
Immunocytochemical double labelling using anti-Myc mouse monoclonal anti-Plexin A1 rabbit polyclonal antibodies in Cos-7 cells mock transfected (A,D) or transfected with Myc-tagged mouse Plexin A1 construct (B,E). The specificity of the binding protein in E was demonstrated using Plexin A1 peptide (ab42757 at 1µg/ml) in the presence of this Plexin A1 antibody (C,F).
ab42757 has not yet been referenced specifically in any publications.