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Dear technical team,
Our customer purchased ab46898.
He said PML-RARA protein has 3 isoforms (S, V, L types) and isoform of L type associate with PML bcr1(Check attached file).
So he would like to know if thisfused peptideis rearranged in bcr1 region.
Because you mentioned as below;
This peptide comprises the region across the PML-RAR alpha junction in the L-type fusion protein.
This issue is important to the customer so please let me know if you have information.
Asked on Jul 24 2012
Thank you for contacting us.
As discussed previously, the PML RARa Fusion peptide is a 10 amino acid residue peptide taken from with the region 500-600 of the PML+RARa Fusion protein. This peptide is ideally suited to being used in blocking peptide studies with the anti-PML+RARA Fusion antibody (ab43152) for which it was used as the immunogen.
This peptide (ab46898) comprises the region across the PML-RAR alpha junction in the L-type fusion protein. The peptide has not been rearranged in any way.
I hope this information has been of help. If you have any further questions, please do not hesitate to ask.
Answered on Jul 24 2012