Overview

Description

  • Nature
    Synthetic
  • Amino Acid Sequence
    • Species
      Human

Associated products

Specifications

Our Abpromise guarantee covers the use of ab41442 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-PSMA antibody (ab41034)

  • Form
    Liquid
  • Additional notes

    - First try to dissolve a small amount of peptide in either water or buffer. The more charged residues on a peptide, the more soluble it is in aqueous solutions.
    - If the peptide doesn’t dissolve try an organic solvent e.g. DMSO, then dilute using water or buffer.
    - Consider that any solvent used must be compatible with your assay. If a peptide does not dissolve and you need to recover it, lyophilise to remove the solvent.
    - Gentle warming and sonication can effectively aid peptide solubilisation. If the solution is cloudy or has gelled the peptide may be in suspension rather than solubilised.
    - Peptides containing cysteine are easily oxidised, so should be prepared in solution just prior to use.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Information available upon request.

General Info

  • Alternative names
    • Cell growth inhibiting protein 27
    • Cell growth-inhibiting gene 27 protein
    • FGCP
    • Folate hydrolase
    • Folate hydrolase (prostate-specific membrane antigen) 1
    • Folate hydrolase 1
    • Folate hydrolase prostate specific membrane antigen 1
    • FOLH
    • FOLH 1
    • Folh1
    • FOLH1_HUMAN
    • Folylpoly gamma glutamate carboxypeptidase
    • Folylpoly-gamma-glutamate carboxypeptidase
    • GCP 2
    • GCP II
    • GCP2
    • GCPII
    • GIG27
    • Glutamate carboxylase II
    • Glutamate carboxypeptidase 2
    • Glutamate carboxypeptidase II
    • Membrane glutamate carboxypeptidase
    • mGCP
    • N acetylated alpha linked acidic dipeptidase 1
    • N-acetylated-alpha-linked acidic dipeptidase I
    • NAALAD 1
    • NAALAD1
    • NAALAdase
    • NAALADase I
    • Prostate specific membrane antigen
    • Prostate specific membrane antigen variant F
    • Prostate-specific membrane antigen
    • PSM
    • PSMA
    • Pteroylpoly gamma glutamate carboxypeptidase
    • Pteroylpoly-gamma-glutamate carboxypeptidase
    see all
  • Function
    Has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Has a preference for tri-alpha-glutamate peptides. In the intestine, required for the uptake of folate. In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N-aceylaspartylglutamate (NAAG), thereby releasing glutamate. Isoform PSM-4 and isoform PSM-5 would appear to be physiologically irrelevant. Involved in prostate tumor progression.
    Also exhibits a dipeptidyl-peptidase IV type activity. In vitro, cleaves Gly-Pro-AMC.
  • Tissue specificity
    Highly expressed in prostate epithelium. Detected in urinary bladder, kidney, testis, ovary, fallopian tube, breast, adrenal gland, liver, esophagus, stomach, small intestine, colon and brain (at protein level). Detected in the small intestine, brain, kidney, liver, spleen, colon, trachea, spinal cord and the capillary endothelium of a variety of tumors. Expressed specifically in jejunum brush border membranes. In the brain, highly expressed in the ventral striatum and brain stem. Also expressed in fetal liver and kidney. Isoform PSMA' is the most abundant form in normal prostate. Isoform PSMA-1 is the most abundant form in primary prostate tumors. Isoform PSMA-2 is also found in normal prostate as well as in brain and liver. Isoform PSMA-9 is specifically expressed in prostate cancer.
  • Sequence similarities
    Belongs to the peptidase M28 family. M28B subfamily.
  • Domain
    The NAALADase activity is found in the central region, the dipeptidyl peptidase IV type activity in the C-terminal.
  • Post-translational
    modifications
    The first two amino acids at the N-terminus of isoform PSMA' appear to be cleaved by limited proteolysis.
    The N-terminus is blocked.
  • Cellular localization
    Cytoplasm and Cell membrane.
  • Information by UniProt

References

ab41442 has not yet been referenced specifically in any publications.

Publishing research using ab41442? Please let us know so that we can cite the reference in this datasheet.

Customer reviews and Q&As

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3 reviews or Q&A

10
Votes: Highest First

Further to the earlier enquiry, I have a few additional questions regarding your PSMA peptide. You have stated that the PSMA peptide (ab41442) is 17 amino acids in length; however, the datasheet provided states the length as 750 amino acids - is this t...

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Thank you for your reply.

You are correct in thinking that the description of the "protein length" described for ab41442 refers to the full length of the PSMA protein from which the peptide is taken. The peptide is described as
<...

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Dear Sir/Madam,

I'm looking to purchase PSMA peptide (ab41442) and I was wondering if you could provide me with the following information which is not available on your datasheet

Stability and shelf life of the peptide.

Formu...

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Thank you for contacting us and your interest in our products.

The PSMA peptide (ab41442) is a 17 amino acid long peptide derived from within the first 100 residues of human PSMA. It was used as the immunogen to produce the anti-PSMA anditbody...

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Thank you very much for the information you provided me with and your very quick response. It was very helpful. I will be purchasing one of these PSMA products from you. I was just wondering if you might be able to tell me why you chose to immunize wit...

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Indeed, ab41442 was used as an immunogen to make one of our PSMA antibodies, ab41034. However, ab97421 has also been used as an immunogen to make another one of our PSMA antibodies, ab71720. Therefore, with regards to your question both peptides a...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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