Overview

Description

  • Nature

    Synthetic
  • Amino Acid Sequence
    • Species

      Human

Specifications

Our Abpromise guarantee covers the use of ab135942 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking

  • Form

    Liquid
  • Additional notes

    Peptide was evaluated by mass spectrometry and C18 reversed-phase HPLC
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    pH: 8.50
    Constituents: 10% DMSO, 0.6% Tris, 0.15% EDTA, 0.1% BSA

General Info

  • Alternative names

    • CADTK
    • CAK-beta
    • CAKB
    • CAKbeta
    • Calcium regulated non receptor proline rich tyrosine kinase
    • Calcium-dependent tyrosine kinase
    • Cell adhesion kinase beta
    • E430023O05Rik
    • EC 2.7.10.2
    • FADK 2
    • FADK2
    • FAK2
    • FAK2_HUMAN
    • Focal adhesion kinase 2
    • MGC124628
    • PKB
    • Proline-rich tyrosine kinase 2
    • Protein kinase B
    • Protein Tyrosine Kinase 2 Beta
    • Protein-tyrosine kinase 2-beta
    • PTK
    • PTK2B
    • PTK2B protein tyrosine kinase 2 beta
    • PYK2
    • RAFTK
    • RAFTK2
    • Related adhesion focal tyrosine kinase
    see all
  • Function

    Involved in calcium induced regulation of ion channel and activation of the map kinase signaling pathway. May represent an important signaling intermediate between neuropeptide activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. Interacts with the SH2 domain of Grb2. May phosphorylate the voltage-gated potassium channel protein Kv1.2. Its activation is highly correlated with the stimulation of c-Jun N-terminal kinase activity. Involved in osmotic stress-dependent SNCA 'Tyr-125' phosphorylation. In concert with SRC, plays an important role in osteoclastic bone resorption. Both the formation of a SRC-PTK2B complex, and SRC kinase activity are necessary for this function. The Tyr-402 phosphorylated form serves as a docking site for SRC and is important for the organization of the osteoclast actin cytoskeleton and attachment sites and for bone resorption.
  • Tissue specificity

    Most abundant in the brain, with highest levels in amygdala and hippocampus. Low levels in kidney. Also expressed in spleen and lymphocytes.
  • Sequence similarities

    Belongs to the protein kinase superfamily. Tyr protein kinase family. FAK subfamily.
    Contains 1 FERM domain.
    Contains 1 protein kinase domain.
  • Post-translational
    modifications

    Phosphorylated on tyrosine residues in response to various stimuli that elevate the intracellular calcium concentration, as well as by PKC activation. Recruitment by nephrocystin to cell matrix adhesions initiates Tyr-402 phosphorylation. In monocytes, adherence to substrata is required for tyrosine phosphorylation and kinase activation. Angiotensin II, thapsigargin and L-alpha-lysophosphatidic acid (LPA) also induce autophosphorylation and increase kinase activity.
  • Cellular localization

    Cytoplasm. Cell membrane. Interaction with nephrocystin induces the membrane-association of the kinase.
  • Information by UniProt

References

ab135942 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

Question
Answer

Ich freue mich Ihnen mitteilen zu können, dass das Blockingpeptid für ab78209 jetzt in unseren Katalog aufgenommen wurde.

Die Artikelnummer lautet:

ab135942

https://www.abcam.com/index.html?datasheet=135942 (or use the following: https://www.abcam.com/index.html?datasheet=135942).

Wie freuen uns auf Ihre Bestellung und wünschen Ihnen viel Erfolg in Ihrer Forschung.

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