Associated products


Our Abpromise guarantee covers the use of ab26346 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Form

  • Additional notes

    - First try to dissolve a small amount of peptide in either water or buffer. The more charged residues on a peptide, the more soluble it is in aqueous solutions.
    - If the peptide doesn’t dissolve try an organic solvent e.g. DMSO, then dilute using water or buffer.
    - Consider that any solvent used must be compatible with your assay. If a peptide does not dissolve and you need to recover it, lyophilise to remove the solvent.
    - Gentle warming and sonication can effectively aid peptide solubilisation. If the solution is cloudy or has gelled the peptide may be in suspension rather than solubilised.
    - Peptides containing cysteine are easily oxidised, so should be prepared in solution just prior to use.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    Information available upon request.

General Info

  • Alternative names

    • Acute myeloid leukemia 3 protein
    • Alpha subunit 1
    • AML3
    • CBF alpha 1
    • CBF-alpha-1
    • CBFA1
    • CCD
    • CCD1
    • Cleidocranial dysplasia 1
    • Core binding factor
    • Core binding factor runt domain alpha subunit 1
    • Core binding factor subunit alpha 1
    • Core-binding factor subunit alpha-1
    • MGC120022
    • MGC120023
    • Oncogene AML 3
    • Oncogene AML-3
    • OSF 2
    • OSF-2
    • OSF2
    • Osteoblast specific transcription factor 2
    • Osteoblast-specific transcription factor 2
    • OTTHUMP00000016533
    • PEA2 alpha A
    • PEA2-alpha A
    • PEA2aA
    • PEBP2 alpha A
    • PEBP2-alpha A
    • PEBP2A1
    • PEBP2A2
    • PEBP2aA
    • PEBP2aA1
    • Polyomavirus enhancer binding protein 2 alpha A subunit
    • Polyomavirus enhancer-binding protein 2 alpha A subunit
    • Runt domain
    • Runt related transcription factor 2
    • Runt-related transcription factor 2
    • RUNX2
    • SL3 3 enhancer factor 1 alpha A subunit
    • SL3-3 enhancer factor 1 alpha A subunit
    • SL3/AKV core binding factor alpha A subunit
    • SL3/AKV core-binding factor alpha A subunit
    see all
  • Function

    Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters (By similarity). Inhibits MYST4-dependent transcriptional activation.
  • Tissue specificity

    Specifically expressed in osteoblasts.
  • Involvement in disease

    Defects in RUNX2 are the cause of cleidocranial dysplasia (CLCD) [MIM:119600]; also known as cleidocranial dysostosis (CCD). CLCD is an autosomal dominant skeletal disorder with high penetrance and variable expressivity. It is due to defective endochondral and intramembranous bone formation. Typical features include hypoplasia/aplasia of clavicles, patent fontanelles, wormian bones (additional cranial plates caused by abnormal ossification of the calvaria), supernumerary teeth, short stature, and other skeletal changes. In some cases defects in RUNX2 are exclusively associated with dental anomalies.
  • Sequence similarities

    Contains 1 Runt domain.
  • Domain

    A proline/serine/threonine rich region at the C-terminus is necessary for transcriptional activation of target genes and contains the phosphorylation sites.
  • Post-translational

    Phosphorylated; probably by MAP kinases (MAPK) (By similarity). Isoform 3 is phosphorylated on Ser-340.
  • Cellular localization

  • Information by UniProt


This product has been referenced in:

  • David V  et al. Mechanical loading down-regulates peroxisome proliferator-activated receptor gamma in bone marrow stromal cells and favors osteoblastogenesis at the expense of adipogenesis. Endocrinology 148:2553-62 (2007). Read more (PubMed: 17317771) »
See 1 Publication for this product

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