Description

  • Product name

    Human S1P peptide
  • Purity

    > 90 % n/a.

  • Accession

  • Animal free

    No
  • Nature

    Synthetic
    • Species

      Human

Associated products

Specifications

Our Abpromise guarantee covers the use of ab223083 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-S1P antibody (ab140592)

  • Form

    Lyophilised
  • Additional notes

    Blocking peptide for 140592

    - First try to dissolve a small amount of peptide in either water or buffer. The more charged residues on a peptide, the more soluble it is in aqueous solutions.

    - If the peptide doesn’t dissolve try an organic solvent e.g. DMSO, then dilute using water or buffer.

    - Consider that any solvent used must be compatible with your assay. If a peptide does not dissolve and you need to recover it, lyophilise to remove the solvent.

    - Gentle warming and sonication can effectively aid peptide solubilisation. If the solution is cloudy or has gelled the peptide may be in suspension rather than solubilised.

    - Peptides containing cysteine are easily oxidised, so should be prepared in solution just prior to use.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20°C.

General Info

  • Alternative names

    • kexin isozyme 1
    • KIAA0091
    • MBTPS1
    • membrane bound transcription factor peptidase, site 1
    • MGC138711
    • MGC138712
    • PCSK8
    • S1P
    • S1P endopeptidase
    • Site 1 protease
    • SKI 1
    • SKI1
    • Subtilisin isozyme 1
    • Subtilisin/kexin isozyme 1
    see all
  • Relevance

    S1P (also known as MBTPS1,SKI1), was first discovered as one of two enzymes that cleave the sterol regulatory binding proteins (SREBPs), in the case of S1P at “site-1,” a hydrophillic loop extending into the lumen of the ER. The MBTPS1 domain structure contains a signal sequence followed by a propeptide domain, a catalytic domain, a transmembrane domain and a cytoplasmic domain.
  • Cellular localization

    Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein.

References

ab223083 has not yet been referenced specifically in any publications.

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