Product nameHuman SAMSN1 peptide
See all SAMSN1 proteins and peptides
Amino Acid Sequence
Our Abpromise guarantee covers the use of ab45611 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Blocking - Blocking peptide for Anti-SAMSN1 antibody (ab21206)
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
- Hematopoietic adapter containing SH3 and sterile α motif (SAM) domains 1
- Hematopoietic adapter containing SH3 and sterile alpha motif (SAM) domains 1
FunctionNegative regulator of B-cell activation. Down-regulates cell proliferation (in vitro). Promotes RAC1-dependent membrane ruffle formation and reorganization of the actin cytoskeleton. Regulates cell spreading and cell polarization. Stimulates HDAC1 activity. Regulates LYN activity by modulating its tyrosine phosphorylation.
Tissue specificityDetected in peripheral blood B-cells (at protein level). Detected in spleen, liver and peripheral blood.
Sequence similaritiesContains 1 SAM (sterile alpha motif) domain.
Contains 1 SH3 domain.
Cellular localizationNucleus. Cytoplasm. Cell projection > ruffle. Shuttles between cytoplasm and nucleus. Colocalizes with the actin cytoskeleton and actin-rich membrane ruffles.
- Information by UniProt
ab45611 has not yet been referenced specifically in any publications.