sterile alpha and HEAT/Armadillo motif protein, ortholog of Drosophila
sterile alpha and HEAT/Armadillo motifs-containing protein
sterile alpha and TIR motif containing 1
Sterile alpha and TIR motif-containing protein 1
Sterile alpha and TIR motifs-containing protein 1
Sterile alpha motif domain-containing protein 2
Involved in innate immnune response. Acts as a negative regulator of TICAM1/TRIF-dependent Toll-like receptor signaling by inhibiting induction of TLR3- and TLR4-dependent genes. Specifically blocks TICAM1/TRIF-dependent transcription-factor activation and gene induction, without affecting the MYD88-dependent pathway or non-TLR signaling. Negative regulator of NF-kappa-B and IRF activation.
Predominantly expressed in kidney and liver. Expressed at lower level in placenta.
Contains 2 SAM (sterile alpha motif) domains. Contains 1 TIR domain.