Product nameHuman SIAH Interacting Protein peptide
See all SIAH Interacting Protein proteins and peptides
Amino Acid Sequence
Amino acids215 to 228
Our Abpromise guarantee covers the use of ab23014 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Concentration information loading...
Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
- Calcyclin binding protein
- Calcyclin-binding protein
FunctionMay be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1).
Sequence similaritiesContains 1 CS domain.
Contains 1 SGS domain.
modificationsPhosphorylated on serine residues. Phosphorylated upon induction by RA or at high calcium concentrations.
Cellular localizationNucleus. Cytoplasm. Cytoplasmic at low calcium concentrations. In neuroblastoma cells, after a retinoic acid (RA) induction and calcium increase, it localizes in both the nucleus and cytoplasm. The nuclear fraction may be phosphorylated.
- Information by UniProt
ab23014 has not yet been referenced specifically in any publications.