Description

  • Product name

    Human SLC17A5 peptide
  • Animal free

    No
  • Nature

    Synthetic
    • Species

      Human

Associated products

Specifications

Our Abpromise guarantee covers the use of ab178604 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-SLC17A5 antibody (ab69819)

  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20°C. Avoid freeze / thaw cycle.

General Info

  • Alternative names

    • AST
    • H(+)/nitrate cotransporter
    • H(+)/sialic acid cotransporter
    • ISSD
    • Membrane glycoprotein HP59
    • NSD
    • S17A5_HUMAN
    • SD
    • Sialic acid storage disease
    • Sialin
    • SIASD
    • Slc17a5
    • SLD
    • Solute carrier family 17 (anion/sugar transportermember 5
    • Solute carrier family 17 member 5
    • Vesicular H(+)/Aspartate-glutamate cotransporter
    see all
  • Function

    Transports glucuronic acid and free sialic acid out of the lysosome after it is cleaved from sialoglycoconjugates undergoing degradation, this is required for normal CNS myelination. Mediates aspartate and glutamate membrane potential-dependent uptake into synaptic vesicles and synaptic-like microvesicles. Also functions as an electrogenic 2NO(3)(-)/H(+) cotransporter in the plasma membrane of salivary gland acinar cells, mediating the physiological nitrate efflux, 25% of the circulating nitrate ions is typically removed and secreted in saliva.
  • Tissue specificity

    Found in fetal lung and small intestine, and at lower level in fetal skin and muscle. In the adult, detected in placenta, kidney and pancreas. Abundant in the endothelial cells of tumors from ovary, colon, breast and lung, but is not detected in endothelial cells from the corresponding normal tissues.
  • Involvement in disease

    Salla disease
    Infantile sialic acid storage disorder
  • Sequence similarities

    Belongs to the major facilitator superfamily. Sodium/anion cotransporter family.
  • Cellular localization

    Cell membrane. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. Lysosome membrane.
  • Information by UniProt

References

ab178604 has not yet been referenced specifically in any publications.

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